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Tytuł:
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Maca Root ( Lepidium meyenii ) Extract Increases the Expression of MMP-1 and Stimulates Migration of Triple-Negative Breast Cancer Cells.
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Autorzy:
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Bizinelli D; University Center of Hermínio Ometto Foundation - FHO, Araras, São Paulo, Brazil.
Flores Navarro F; University Center of Hermínio Ometto Foundation - FHO, Araras, São Paulo, Brazil.
Lima Costa Faldoni F; University Center of Hermínio Ometto Foundation - FHO, Araras, São Paulo, Brazil.; Department of Gynecology and Obstetrics, Medical School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
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Źródło:
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Nutrition and cancer [Nutr Cancer] 2022; Vol. 74 (1), pp. 346-356. Date of Electronic Publication: 2021 Feb 09.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Philadelphia : Routledge
Original Publication: Philadelphia, Franklin Institute Press.
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MeSH Terms:
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Lepidium*
Triple Negative Breast Neoplasms*/drug therapy
Humans ; Matrix Metalloproteinase 1/genetics ; Plant Extracts/pharmacology ; Spermatozoa
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Substance Nomenclature:
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0 (Plant Extracts)
EC 3.4.24.7 (Matrix Metalloproteinase 1)
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Entry Date(s):
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Date Created: 20210209 Date Completed: 20220224 Latest Revision: 20220224
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Update Code:
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20240104
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DOI:
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10.1080/01635581.2021.1882511
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PMID:
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33560149
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Maca root ( Lepidium meyenii ) extract is a worldwide consumed food supplement for sexual dysfunctions, increasing sperm production and its motility, and alleviating menopausal symptoms. Once maca root has a role in cell proliferation and motility, and its consumption may increase along with age, mainly in menopausal women, we aimed to investigate the plant effects on triple-negative breast cancer (TNBC) cell lines. Standardized maca root powdered extract showed significant cytotoxic activity in both MDA-MB-231 and Hs578T cells, and the IC 50 s were 2000 μg/ml and 3000 μg/ml, respectively. Both cell lines showed an increase in migratory capacity. Using bioinformatics tools, we established genes involved in the metastatic process, CAV1 , LAMA4 , and MMP-1 , and the mRNAs expression was assessed by qPCR. Comparing the treated cells to the negative control, CAV1 presented a decreased expression by 2-fold in MDA-MB-231. LAMA4 presented a decrease by 4-fold in Hs578T cells. MMP-1 showed substantially increase mRNA expression in MDA-MB-231 by 86-fold and in Hs578T by 5-fold. To the best of our knowledge, this is the first study indicating that the human consumption of maca may be dangerous due to the upregulation in MMP-1 expression and the increase in TNBC migrated cells.
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