Selected Thoughts on Hydrophobicity in Drug Design.

Tytuł:: Selected Thoughts on Hydrophobicity in Drug Design.
Autorzy:: Lou LL; Nexus Development PA, Redwood City, CA 94065, USA.
Martin JC; Nexus Development PA, Redwood City, CA 94065, USA.
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Feb 07; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 07.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, c1995-
MeSH Terms:: Drug Design*
Antiviral Agents/*chemistry
Nucleosides/*chemistry
Organophosphonates/*chemistry
Antiviral Agents/therapeutic use ; Drug Discovery ; Humans ; Hydrophobic and Hydrophilic Interactions/drug effects
References:: Antimicrob Agents Chemother. 2005 May;49(5):1898-906. (PMID: 15855512)
J Hepatol. 2015 Mar;62(3):533-40. (PMID: 25450717)
J Med Chem. 1986 May;29(5):671-5. (PMID: 3009811)
Angew Chem Int Ed Engl. 2013 Nov 18;52(47):12256-67. (PMID: 24151256)
J Viral Hepat. 2019 May;26(5):561-567. (PMID: 30576085)
J Am Chem Soc. 1997 Jan 29;119(4):681-90. (PMID: 16526129)
Science. 1993 Jun 4;260(5113):1510-3. (PMID: 7684856)
Nature. 1986 Oct 2-8;323(6087):464-7. (PMID: 3762696)
J Med Chem. 1983 May;26(5):759-61. (PMID: 6302255)
Antimicrob Agents Chemother. 1983 May;23(5):676-82. (PMID: 6307132)
Antimicrob Agents Chemother. 1994 Sep;38(9):2180-2. (PMID: 7811041)
J Med Chem. 2012 May 10;55(9):4489-500. (PMID: 22500930)
J Clin Transl Hepatol. 2013 Sep;1(1):33-8. (PMID: 26357604)
Antimicrob Agents Chemother. 2015;59(6):3563-9. (PMID: 25870059)
Chem Rev. 2011 Sep 14;111(9):5215-46. (PMID: 21631125)
Antiviral Res. 1992 Sep;19(3):267-73. (PMID: 1332606)
Antimicrob Agents Chemother. 2015 Oct;59(10):5909-16. (PMID: 26149992)
J Med Chem. 1992 Aug 7;35(16):2958-69. (PMID: 1323678)
Antimicrob Agents Chemother. 1993 Feb;37(2):332-8. (PMID: 8452366)
Antiviral Res. 2010 Jan;85(1):34-8. (PMID: 19854224)
J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55. (PMID: 23807155)
J Am Chem Soc. 1968 Sep 11;90(19):5336-8. (PMID: 5670802)
Antimicrob Agents Chemother. 2006 Jul;50(7):2471-7. (PMID: 16801428)
Antivir Chem Chemother. 1999 Jul;10(4):141-54. (PMID: 10480735)
Contributed Indexing:: Keywords: acyclic nucleoside phosphonates; drug design; hydrophobic interaction; nucleotide antivirals
Substance Nomenclature:: 0 (Antiviral Agents)
0 (Nucleosides)
0 (Organophosphonates)
Entry Date(s):: Date Created: 20210210 Date Completed: 20210412 Latest Revision: 20210412
Update Code:: 20240104
PubMed Central ID:: PMC7914489
DOI:: 10.3390/molecules26040875
PMID:: 33562230
: Czasopismo naukowe

Pełny tekst

The fundamental aim of drug design in research and development is to invent molecules with selective affinity towards desired disease-associated targets. At the atomic loci of binding surfaces, systematic structural variations can define affinities between drug candidates and biomolecules, and thereby guide the optimization of safety, efficacy and pharmacologic properties. Hydrophobic interaction between biomolecules and drugs is integral to binding affinity and specificity. Examples of antiviral drug discovery are discussed.

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja