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Tytuł:
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Dietary carbohydrate intake and insulin traits in individuals after acute pancreatitis: Effect modification by intra-pancreatic fat deposition.
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Autorzy:
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Ko J; School of Medicine, University of Auckland, Auckland, New Zealand.
Kimita W; School of Medicine, University of Auckland, Auckland, New Zealand.
Skudder-Hill L; School of Medicine, University of Auckland, Auckland, New Zealand.
Li X; School of Medicine, University of Auckland, Auckland, New Zealand.
Priya S; School of Medicine, University of Auckland, Auckland, New Zealand.
Bharmal SH; School of Medicine, University of Auckland, Auckland, New Zealand.
Cho J; School of Medicine, University of Auckland, Auckland, New Zealand.
Petrov MS; School of Medicine, University of Auckland, Auckland, New Zealand. Electronic address: .
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Źródło:
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Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2021 Mar; Vol. 21 (2), pp. 353-362. Date of Electronic Publication: 2021 Feb 02.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2012- : New Delhi : Elsevier India
Original Publication: Basel ; New York : Karger, c2001-
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MeSH Terms:
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Dietary Carbohydrates/*administration & dosage
Insulin/*metabolism
Pancreatitis/*pathology
Acute Disease ; Adult ; Aged ; Blood Glucose ; Body Composition ; Female ; Humans ; Male ; Middle Aged ; Pancreatitis/diagnosis ; Pancreatitis/metabolism
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Contributed Indexing:
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Keywords: Diet; Insulin traits; Intra-pancreatic fat; Pancreas; Pancreatitis
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Substance Nomenclature:
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0 (Blood Glucose)
0 (Dietary Carbohydrates)
0 (Insulin)
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Entry Date(s):
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Date Created: 20210210 Date Completed: 20211105 Latest Revision: 20211105
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Update Code:
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20240105
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DOI:
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10.1016/j.pan.2021.01.018
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PMID:
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33563551
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Objectives: Current knowledge of the link between dietary carbohydrate intake and insulin regulation in individuals after an attack of pancreatitis is limited. We aimed to investigate the associations between dietary carbohydrate intake and insulin traits in post-pancreatitis versus healthy individuals, taking into account intrapancreatic fat deposition (IPFD).
Methods: All participants underwent magnetic resonance imaging (using the same protocol and 3T scanner) to quantify IPFD. Dietary carbohydrate intake was assessed using a validated 131-item food frequency questionnaire. Insulin, HOMA-IR, HOMA-β were determined in the fasted state. Linear regression and effect modification analyses were conducted in unadjusted and adjusted models (accounting for age, sex, body mass index, daily energy intake, use of anti-diabetic medications, and recurrence of acute pancreatitis).
Results: The study included 111 post-pancreatitis individuals (categorized into low IPFD (n = 33), moderate IPFD (n = 40), high IPFD (n = 38)) and 47 healthy controls. In the high IPFD group, starch intake was negatively associated with fasting insulin and HOMA-β in both the unadjusted (p < 0.001 both) and fully adjusted models (p < 0.001 both); and with HOMA-IR in the fully adjusted model (p < 0.001) only. Total sugar intake was positively associated with fasting insulin (p = 0.015) and HOMA-β (p = 0.007) in the fully adjusted model but not associated with HOMA-IR. None of the above associations was statistically significant in the low IPFD, moderate IPFD, and healthy controls groups. The studied associations were more pronounced in the high IPFD group but not in the moderate IPFD or low IPFD groups (when compared with the healthy controls group).
Conclusions: Dietary carbohydrate intake is differentially associated with insulin traits in individuals after an attack of pancreatitis and the associations are modified by IPFD. These findings will be helpful for the development of dietary guidelines specifically for individuals after an attack of pancreatitis.
(Copyright © 2021 IAP and EPC. Published by Elsevier B.V. All rights reserved.)
