Truly epigenetic: A centromere finds a "neo" home.

Tytuł:: Truly epigenetic: A centromere finds a "neo" home.
Autorzy:: Carty BL; Centre for Chromosome Biology, Biomedical Sciences, National University of Ireland Galway, Galway, Ireland.
Dunleavy EM; Centre for Chromosome Biology, Biomedical Sciences, National University of Ireland Galway, Galway, Ireland.
Źródło:: The Journal of cell biology [J Cell Biol] 2021 Mar 01; Vol. 220 (3).
Typ publikacji:: Journal Article; Comment
Język:: English
Imprint Name(s):: Original Publication: New York : Rockefeller University Press
MeSH Terms:: Centromere*/genetics
Epigenomics*
Centromere Protein A/genetics ; Epigenesis, Genetic ; Humans
References:: J Cell Biol. 2021 Mar 1;220(3):. (PMID: 33443568)
Mol Cell Biol. 2018 Aug 28;38(18):. (PMID: 29941491)
Chromosome Res. 2012 Jul;20(5):607-19. (PMID: 22723125)
PLoS Genet. 2009 Mar;5(3):e1000400. (PMID: 19266018)
Nat Rev Mol Cell Biol. 2016 Jan;17(1):16-29. (PMID: 26601620)
Substance Nomenclature:: 0 (Centromere Protein A)
Entry Date(s):: Date Created: 20210210 Date Completed: 20210906 Latest Revision: 20231110
Update Code:: 20240105
PubMed Central ID:: PMC7879491
DOI:: 10.1083/jcb.202101027
PMID:: 33566070
: Czasopismo naukowe

Murillo-Pineda and colleagues (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202007210) use CRISPR-Cas9-based genetic engineering in human cells to induce a new functional centromere at a naive chromosomal site. Long-read DNA sequencing at the neocentromere provides firm evidence that centromere establishment is a truly epigenetic event.
(© 2021 Carty and Dunleavy.)

Comment on: J Cell Biol. 2021 Mar 1;220(3):. (PMID: 33443568)

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