Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans.

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Abstrakt

Tytuł:: Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans.
Autorzy:: Haemmig S; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Hashemi Gheinani A; Department of Surgery, Urological Diseases Research Center, Boston Children Hospital (A.H.G.), Harvard Medical School, Boston, MA.; Broad Institute of MIT and Harvard, Cambridge, MA (A.H.G.).
Zaromytidou M; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Siasos G; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Coskun AU; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Cormier MA; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Gross DA; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Wara AKMK; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Antoniadis AP; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Sun X; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Sukhova GK; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Welt FGP; Division of Cardiovascular Medicine, University of Utah Health Sciences Center, Salt Lake City (F.G.P.W.).
Andreou I; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Whatling C; Bioscience Cardiovascular/Early Clinical Development/Translational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden (C.W., L.-M.G., J.W.).
Gan LM; Bioscience Cardiovascular/Early Clinical Development/Translational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden (C.W., L.-M.G., J.W.).
Wikström J
Edelman ER; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge (E.R.E.).
Libby P; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Stone PH; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Feinberg MW; Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital (S.H., M.Z., G.S., A.U.C., M.A.C., D.A.G., A.K.W., A.P.A., X.S., G.K.S., I.A., E.R.E., P.L., P.H.S., M.W.F.), Harvard Medical School, Boston, MA.
Źródło:: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Apr; Vol. 41 (4), pp. 1487-1503. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji:: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins
Original Publication: Dallas, TX : American Heart Association, c1995-
MeSH Terms:: Gene Expression Profiling*
Plaque, Atherosclerotic*
Transcriptome*
Carotid Artery Diseases/*genetics
Coronary Artery Disease/*genetics
Diabetes Mellitus, Type 2/*genetics
Aged ; Aged, 80 and over ; Animals ; Carotid Artery Diseases/metabolism ; Carotid Artery Diseases/pathology ; Coronary Artery Disease/metabolism ; Coronary Artery Disease/pathology ; Diabetes Mellitus, Experimental/diagnosis ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/metabolism ; Disease Progression ; Female ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; Hypercholesterolemia/genetics ; Hypercholesterolemia/metabolism ; Machine Learning ; Male ; Middle Aged ; RNA-Seq ; Severity of Illness Index ; Signal Transduction ; Sus scrofa
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Grant Information:: R01 HL153356 United States HL NHLBI NIH HHS; R01 GM049039 United States GM NIGMS NIH HHS; R01 HL134892 United States HL NHLBI NIH HHS; R01 HL148355 United States HL NHLBI NIH HHS; R01 HL115141 United States HL NHLBI NIH HHS; R01 HL148207 United States HL NHLBI NIH HHS; R01 HL134849 United States HL NHLBI NIH HHS
Contributed Indexing:: Keywords: algorithms; atherosclerosis; coronary vessels; mitochondria; technology
Entry Date(s):: Date Created: 20210211 Date Completed: 20210601 Latest Revision: 20240331
Update Code:: 20240331
PubMed Central ID:: PMC7990701
DOI:: 10.1161/ATVBAHA.121.315896
PMID:: 33567868
: Czasopismo naukowe

[Figure: see text].

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