Clinical Implications of Multiplex Pathogen Panels for the Diagnosis of Acute Viral Gastroenteritis.

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Abstrakt

Tytuł:: Clinical Implications of Multiplex Pathogen Panels for the Diagnosis of Acute Viral Gastroenteritis.
Autorzy:: Wilber E; Division of General Internal Medicine & Geriatrics, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Baker JM; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Rebolledo PA; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Źródło:: Journal of clinical microbiology [J Clin Microbiol] 2021 Jul 19; Vol. 59 (8), pp. e0151319. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Washington, American Society for Microbiology.
MeSH Terms:: Antimicrobial Stewardship*
Enteritis*
Gastroenteritis*/diagnosis
Viruses*/genetics
Feces ; Humans ; Multiplex Polymerase Chain Reaction
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Grant Information:: T32 AI074492 United States AI NIAID NIH HHS
Contributed Indexing:: Keywords: acute gastroenteritis; molecular diagnostics; viral
Entry Date(s):: Date Created: 20210211 Date Completed: 20210805 Latest Revision: 20240214
Update Code:: 20240214
PubMed Central ID:: PMC8288264
DOI:: 10.1128/JCM.01513-19
PMID:: 33568466
: Czasopismo naukowe

Acute gastroenteritis remains a significant cause of morbidity and mortality in both high- and low-resource settings. The development of nucleic acid-based testing has demonstrated that viruses are a common, yet often undetected, cause of acute gastroenteritis. The development of multiplex pathogen PCR panels makes it possible to detect these viral pathogens with greater sensitivity and rapidity than with previous methods. At present, there is insufficient evidence to recommend the routine use of these panels for the average patient with acute gastroenteritis. However, there are specific scenarios and patient populations, such as epidemiology/outbreak surveillance, antimicrobial stewardship, and the care of immunocompromised patients, where these tests could be clinically useful today. Further research on the effect of these syndromic panels on provider antibiotic prescribing behavior and patient length of stay will be necessary to know their ultimate role in clinical practice.

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