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Tytuł pozycji:

Evaluation of maternal high-fat diet and Quercetin-3-O-rutinoside treatment on the reproductive profile of diet naïve male offspring.

Tytuł:
Evaluation of maternal high-fat diet and Quercetin-3-O-rutinoside treatment on the reproductive profile of diet naïve male offspring.
Autorzy:
Adeyemi TE; Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa. Electronic address: .
Channa ML; Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa. Electronic address: .
Nadar A; Discipline of Human Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa. Electronic address: .
Źródło:
Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119179. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
MeSH Terms:
Diet, High-Fat/*adverse effects
Glucosides/*pharmacology
Maternal Nutritional Physiological Phenomena/*physiology
Prenatal Exposure Delayed Effects/*metabolism
Quercetin/*analogs & derivatives
Reproduction/*physiology
Testis/*metabolism
Animals ; Female ; Gonadotropin-Releasing Hormone/metabolism ; Male ; Maternal Nutritional Physiological Phenomena/drug effects ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Quercetin/pharmacology ; Rats ; Rats, Sprague-Dawley ; Reproduction/drug effects ; Testis/drug effects ; Testosterone/metabolism
Contributed Indexing:
Keywords: Adipokines; Developmental programming; High-fat diet; Male fertility; Pro-inflammatory cytokines; Sex hormones
Substance Nomenclature:
0 (Glucosides)
0 (quercetin-3-O-rutinoside)
33515-09-2 (Gonadotropin-Releasing Hormone)
3XMK78S47O (Testosterone)
9IKM0I5T1E (Quercetin)
Entry Date(s):
Date Created: 20210212 Date Completed: 20210317 Latest Revision: 20210317
Update Code:
20240104
DOI:
10.1016/j.lfs.2021.119179
PMID:
33577849
Czasopismo naukowe
Background: Male infertility and reproductive dysfunctions have become major global health problems. Although several causative factors have been attributed to this challenge, of importance are alterations in maternal-foetal environment, diet-induced transcriptional changes and dysregulation in chemical signaling via hypothalamic-gonadal axis.
Aim: The present study investigated the impact of maternal high-fat diet (HFD) consumption and the putative role of Quercetin-3-O-rutinoside on reproductive functions of male offspring rats at critical developmental stages with a quest to unravel the underpinned molecular changes.
Materials and Methods: Fifty-six pregnant rats (previously fed normal diet ND) or 45% HFD) were maintained on supplemented chow (150 mg/kg QR) - ND/QR, HFD/QR throughout gestation. Subsequently, dams (n = 7) and offspring (n = 6) were sacrificed at post-natal day (PND) 21, 28 and 35, respectively, and the blood, placenta, hypothalamus (HT), and testicular samples were processed for molecular analysis of Gonadotropin-releasing hormone (GnRH), Luteinizing hormone (LH), testosterone, chemerin, chemokine-like receptor 1 (CMKLR1), tumour necrosis factor α (TNF-α), interleukin 1β (IL-1β) and nuclear factor kappa B (NF-κB).
Key Findings: We observed a significant decrease in GnRH level in the HFD group at PND21 and PND28 in male offspring and treatment with QR significantly reduced GnRH. There was a significant reduction in LH levels in the HFD group at PND 21 in the male offspring accompanied by a significant decrease in testosterone level at PND 28 and PND35 which appears to be age dependent. In the HT, Chemerin and CMKLR1 was significantly upregulated in the HFD group at PND 21 and PND 35 respectively while CMKLR1 was significantly downregulated in the HFD group of the placenta and testis at PND 21. TNF-α, IL-1β and NF-κB were also expressed in the placenta, HT and testis at PND 21.
Significance: Male fertility is affected by maternal HFD consumption while chemerin, CMKLR1 and TNF-α, may play a significant role in male steroidogenesis. Treatment with QR had little or no ameliorative effect on HFD induced alterations in male reproductive functions.
(Copyright © 2021 Elsevier Inc. All rights reserved.)

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