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Tytuł pozycji:

Octahedral ruthenium and magnesium naringenin 5-alkoxide complexes: NMR analysis of diastereoisomers and in-vivo antibacterial activity against Xylella fastidiosa.

Tytuł :
Octahedral ruthenium and magnesium naringenin 5-alkoxide complexes: NMR analysis of diastereoisomers and in-vivo antibacterial activity against Xylella fastidiosa.
Autorzy :
da Silva DF; Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP, Brazil.
Amaral JC; Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP, Brazil.
Carlos RM; Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP, Brazil.
Ferreira AG; Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP, Brazil.
Forim MR; Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP, Brazil.
Fernandes JB; Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP, Brazil.
da Silva MFDGF; Departamento de Química, Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP, Brazil. Electronic address: .
Filho HDC; Centro APTA Citros Sylvio Moreira, Instituto Agronômico, CP 04, 13490-970, Cordeirópolis, SP, Brazil.
de Souza AA; Centro APTA Citros Sylvio Moreira, Instituto Agronômico, CP 04, 13490-970, Cordeirópolis, SP, Brazil.
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Źródło :
Talanta [Talanta] 2021 Apr 01; Vol. 225, pp. 122040. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Amsterdam : Elsevier
Original Publication: Oxford : Pergamon Press
MeSH Terms :
Anti-Infective Agents*
Citrus*
Ruthenium*
Xylella*
Anti-Bacterial Agents/pharmacology ; Flavanones ; Magnesium ; Magnetic Resonance Spectroscopy ; Plant Diseases
Contributed Indexing :
Keywords: Bactericides; Citrus; Nuclear magnetic resonance; Real-time quantitative PCR; Xylella fastidiosa
Substance Nomenclature :
0 (Anti-Bacterial Agents)
0 (Anti-Infective Agents)
0 (Flavanones)
7UI0TKC3U5 (Ruthenium)
HN5425SBF2 (naringenin)
I38ZP9992A (Magnesium)
SCR Organism :
Xylella fastidiosa
Entry Date(s) :
Date Created: 20210217 Date Completed: 20210514 Latest Revision: 20210514
Update Code :
20210515
DOI :
10.1016/j.talanta.2020.122040
PMID :
33592764
Czasopismo naukowe
Although many copper-based antimicrobial compounds have been developed to control pathogenic bacteria and fungi in plants and applied for crop protection, there is evidence that several plant pathogens have developed resistance to copper-based antimicrobial compounds, including some Xanthomonas species. Xylella is a bacterial genus belonging to the Xanthomonas family; and X. fastidiosa, which is responsible for citrus variegated chlorosis (CVC) in sweet orange, may develop resistance to one or more copper-based antimicrobials. Because of the time required for the development and approval of new antimicrobials for commercial use, the discovery of novel bactericidal compounds is essential before the development of resistance to the antimicrobials currently in use becomes widespread. Here, we explored the antimicrobial potential of two newly synthesized antimicrobials complexes and one natural compound against X. fastidiosa. Several nuclear magnetic resonance (NMR) assays with high resolution and sensitivity were developed to identify new diastereoisomers in the context of octahedral ruthenium - [Ru(narin)(phen) 2 ]PF 6- and magnesium naringenin 5-alkoxide - [Mg(narin)(phen) 2 ]OAc - complexes, obtained in the present work. The NMR assays proved to be powerful tools for the identification of isomers in metal complexes. Moreover, a protocol for the in-vivo determination of the effects of these complexes against X. fastidiosa was developed. The main trunks of X. fastidiosa infected plants were injected with the two complexes as well as with the limonoid azadirachtin using a syringe; the number of bacterial cells in the plants following treatment was estimated via real-time quantitative PCR (qPCR). Importantly, the administration of both complexes and of azadirachtin drastically reduced the number of X. fastidiosa cells in vivo.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

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