Effect of robot-assisted gait training on gait automaticity in Parkinson disease: A prospective, open-label, single-arm, pilot study.

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Tytuł:: Effect of robot-assisted gait training on gait automaticity in Parkinson disease: A prospective, open-label, single-arm, pilot study.
Autorzy:: Yun SJ; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital.
Lee HH; Department of Rehabilitation Medicine, Konkuk University Medical Center.
Lee WH; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital.
Lee SH; Department of Rehabilitation Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Republic of Korea.
Oh BM; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital.
Seo HG; Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital.
Źródło:: Medicine [Medicine (Baltimore)] 2021 Feb 05; Vol. 100 (5), pp. e24348.
Typ publikacji:: Clinical Trial; Journal Article
Język:: English
Imprint Name(s):: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
MeSH Terms:: Exoskeleton Device*
Exercise Therapy/*instrumentation
Gait Disorders, Neurologic/*therapy
Parkinson Disease/*therapy
Robotics/*instrumentation
Aged ; Exercise Therapy/methods ; Female ; Gait/physiology ; Gait Analysis ; Gait Disorders, Neurologic/etiology ; Gait Disorders, Neurologic/physiopathology ; Humans ; Male ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/physiopathology ; Pilot Projects ; Prospective Studies ; Republic of Korea ; Robotics/methods ; Treatment Outcome
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Grant Information:: NRCTR-EX18009 The Translational Research Center for Rehabilitation Robots, National Rehabilitation Center, Ministry of Health and Welfare, Korea
Entry Date(s):: Date Created: 20210217 Date Completed: 20210223 Latest Revision: 20240330
Update Code:: 20240330
PubMed Central ID:: PMC7870221
DOI:: 10.1097/MD.0000000000024348
PMID:: 33592882
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Abstract: Gait automaticity is reduced in patients with Parkinson disease (PD) due to impaired habitual control. The aim of this study was to investigate the effect of robot-assisted gait training (RAGT) on gait automaticity as well as gait speed and balance in patients with PD.This study was a prospective, open-label, single-arm, pilot study. We planned to recruit 12 patients with idiopathic PD. Participants received 12 sessions of RAGT using exoskeleton-type robotic device. Sessions were 45-minute each, 3 days a week, for 4 consecutive weeks using an exoskeleton-type gait robot. The primary outcome was the percentage of dual-task interference measured by the 10-Meter Walk Test (10MWT) under single and dual-task (cognitive and physical) conditions. Secondary outcomes were the Berg Balance Scale and Korean version of the Falls Efficacy Scale-International. All measures were evaluated before treatment (T0), after treatment (T1), and 1-month post-treatment (T2).Twelve patients were enrolled and 1 dropped out. Finally, 11 patients with idiopathic PD were analyzed. The mean age of 11 patients (5 males) was 66.46 ± 5.66 years, and disease duration was 112.91 ± 50.19 months. The Hoehn and Yahr stages were 2.5 in 8 patients and 3 in 3 patients. Linear mixed-effect model analysis showed a significant change over time only in single-task gait speed of the 10MWT (P = .007), but not in dual-task gait speed, dual-task interferences, and Korean version of the Falls Efficacy Scale-International. Cognitive dual-task interference significantly increased (P = .026) at T1, but not at T2 (P = .203). No significant changes were observed for physical dual-task interference at T1 and T2. Single-task gait speed of the 10MWT was significantly increased at T1 (P = .041), but not at T2 (P = .445). There were no significant changes in the dual-task gait speed of 10MWT. A significant improvement was observed in Berg Balance Scale score at T1 and T2 (P = .004 and P = .024, respectively).In this pilot study, despite improvement in walking speed and balance, gait automaticity in patients with PD was not improved by RAGT using an exoskeleton-type robot. Additional therapeutic components may be needed to improve gait automaticity using RAGT in patients with PD.
Competing Interests: The authors have no conflicts of interest to disclose.
(Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)

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