Therapeutic Effects of Different Animal Bile Powders on Lipid Metabolism Disorders and Their Composition Analysis.

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Tytuł:: Therapeutic Effects of Different Animal Bile Powders on Lipid Metabolism Disorders and Their Composition Analysis.
Autorzy:: Chen DX; Academy of Integrative Medicine Cardiovascular Research Institute, Fuzhou, 350122, China.; Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.; Chen Ke-ji Academic Thought Heritage Studio, Fuzhou, 350122, China.
Chu JF; Academy of Integrative Medicine Cardiovascular Research Institute, Fuzhou, 350122, China.; Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.; Chen Ke-ji Academic Thought Heritage Studio, Fuzhou, 350122, China.
Lin S; Academy of Integrative Medicine Cardiovascular Research Institute, Fuzhou, 350122, China.; Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.; Chen Ke-ji Academic Thought Heritage Studio, Fuzhou, 350122, China.
Zhang L; Academy of Integrative Medicine Cardiovascular Research Institute, Fuzhou, 350122, China.; Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Chen HW; Academy of Integrative Medicine Cardiovascular Research Institute, Fuzhou, 350122, China.; Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.; Chen Ke-ji Academic Thought Heritage Studio, Fuzhou, 350122, China.
Sun ZW; Academy of Integrative Medicine Cardiovascular Research Institute, Fuzhou, 350122, China.; Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Xu JF; Fujian Guizhentang Pharmaceutical Co., Ltd., Huian, Fujian Province, 362142, China.
Cai QY; Academy of Integrative Medicine Cardiovascular Research Institute, Fuzhou, 350122, China.; Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.; Chen Ke-ji Academic Thought Heritage Studio, Fuzhou, 350122, China.
Wang LL; Academy of Integrative Medicine Cardiovascular Research Institute, Fuzhou, 350122, China.; Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Peng J; Academy of Integrative Medicine Cardiovascular Research Institute, Fuzhou, 350122, China. .; Fujian Key Laboratory of Integrative Medicine on Geriatric, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China. .; Chen Ke-ji Academic Thought Heritage Studio, Fuzhou, 350122, China. .
Źródło:: Chinese journal of integrative medicine [Chin J Integr Med] 2022 Oct; Vol. 28 (10), pp. 918-923. Date of Electronic Publication: 2021 Feb 20.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2007- : Berlin : Chinese Journal of Integrated Traditional and Western Medicine Press : Springer
Original Publication: Beijing, China : Watertown, MA : Chinese Association of the Integration of Traditional and Western Medicine : China Academy of Traditional Chinese Medicine ; Distributed by Relaxing Natural Health, [2003]-
MeSH Terms:: Lipid Metabolism Disorders*/metabolism
Ursidae*/metabolism
Animals ; Bile/chemistry ; Bile/metabolism ; Biomarkers/metabolism ; Body Weight ; Cattle ; Diet, High-Fat ; Female ; Lipid Metabolism ; Lipids/analysis ; Liver/metabolism ; Powders ; Rats ; Rats, Sprague-Dawley ; Swine ; Taurodeoxycholic Acid/analysis ; Taurodeoxycholic Acid/metabolism ; Ursodeoxycholic Acid/analysis ; Ursodeoxycholic Acid/metabolism
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Contributed Indexing:: Keywords: active ingredient; bile powders; lipid metabolism; liver
Substance Nomenclature:: 0 (Biomarkers)
0 (Lipids)
0 (Powders)
516-50-7 (Taurodeoxycholic Acid)
724L30Y2QR (Ursodeoxycholic Acid)
Entry Date(s):: Date Created: 20210220 Date Completed: 20221003 Latest Revision: 20221003
Update Code:: 20240105
DOI:: 10.1007/s11655-021-3441-3
PMID:: 33609233
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Objective: To compare the therapeutic effect of different animal bile powders on lipid metabolism disorders induced by high-fat diet in rats, and analyze the bioactive components of each animal bile powder.
Methods: Sixty Sprague-Dawley rats were randomly divided into 6 groups (n=10): normal diet control group, high-fat diet model group, high-fat diet groups orally treated with bear, pig, cow and chicken bile powders, respectively. Serum biochemical markers from the abdominal aorta in each group were analyzed. Changes in the body weight and liver weight were recorded. Pathohistological changes in the livers were examined. High performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry was used to determine the composition of bioactive components in each animal bile powder.
Results: Treatment with different types of animal bile powders had different inhibitory effects on high-fat diet-induced increase of body weight and/or liver weight in rats, most notably in bear and pig bile powders (P<0.05). High-fat diet induced lipid metabolism disorder in rats, which could be reversed by treatment with all kinds of bile powders. Bear bile and chicken bile showed the most potent therapeutic effect against lipid metabolism disorder. Cow and bear bile effectively alleviated high-fat diet induced liver enlargement and discoloration, hepatocyte swelling, infiltration of inflammatory cells and formation of lipid vacuoles. Bioactive component analysis revealed that there were significant differences in the relative content of taurocholic acid, taurodeoxycholic acid and ursodeoxycholic acid among different types of animal bile. Interestingly, a unique component with molecular weight of 496.2738 Da, whose function has not yet been reported, was identified only in bear bile powder.
Conclusions: Different animal bile powders had varying therapeutic effect against lipid metabolism disorders induced by high-fat diet, and bear bile powder demonstrated the most effective benefits. Bioactive compositions were different in different types of animal bile with a novel compound identified only in bear bile powder.
(© 2021. The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature.)

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