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Tytuł:
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Accumulation of cis- and trans-regulatory variations is associated with phenotypic divergence of a complex trait between yeast species.
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Autorzy:
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Lupo O; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Krieger G; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Jonas F; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Barkai N; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
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Źródło:
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G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Feb 09; Vol. 11 (2).
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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Język:
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English
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Imprint Name(s):
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Publication: 2021- : [Oxford] : Oxford University Press
Original Publication: Bethesda, MD : Genetics Society of America, 2011-
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MeSH Terms:
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Saccharomyces cerevisiae*
Saccharomyces cerevisiae Proteins*
Cell Cycle Proteins ; Evolution, Molecular ; Forkhead Transcription Factors ; Gene Expression Regulation, Fungal ; Multifactorial Inheritance ; Phenotype ; Phylogeny ; Saccharomyces
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References:
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Contributed Indexing:
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Keywords: gene regulation; genome evolution; transcription factors binding
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Molecular Sequence:
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figshare 10.25387/g3.13553690
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Substance Nomenclature:
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0 (Cell Cycle Proteins)
0 (Fkh1 protein, S cerevisiae)
0 (Fkh2 protein, S cerevisiae)
0 (Forkhead Transcription Factors)
0 (Saccharomyces cerevisiae Proteins)
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SCR Organism:
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Saccharomyces paradoxus
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Entry Date(s):
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Date Created: 20210220 Date Completed: 20210706 Latest Revision: 20210706
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Update Code:
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20240105
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PubMed Central ID:
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PMC8022985
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DOI:
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10.1093/g3journal/jkab016
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PMID:
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33609368
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Gene regulatory variations accumulate during evolution and alter gene expression. While the importance of expression variation in phenotypic evolution is well established, the molecular basis remains largely unknown. Here, we examine two closely related yeast species, Saccharomyces cerevisiae and Saccharomyces paradoxus, which show phenotypical differences in morphology and cell cycle progression when grown in the same environment. By profiling the cell cycle transcriptome and binding of key transcription factors (TFs) in the two species and their hybrid, we show that changes in expression levels and dynamics of oscillating genes are dominated by upstream trans-variations. We find that multiple cell cycle regulators show both cis- and trans-regulatory variations, which alters their expression in favor of the different cell cycle phenotypes. Moreover, we show that variations in the cell cycle TFs, Fkh1, and Fkh2 affect both the expression of target genes, and the binding specificity of an interacting TF, Ace2. Our study reveals how multiple variations accumulate and propagate through the gene regulatory network, alter TFs binding, contributing to phenotypic changes in cell cycle progression.
(© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.)