-
Tytuł:
-
Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy.
-
Autorzy:
-
Honda R; Department of Pediatrics, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan; Nagasaki University School of Medicine Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address: .
Baba H; Department of Neurosurgery, Nishiisahaya Hospital, Nagasaki, Japan; Department of Neurosurgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
Adachi K; Department of Comprehensive Community Care Services, Nagasaki Junshin Catholic University, Japan.
Koshimoto R; Psychological Counselling Center, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
Ono T; Department of Neurosurgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
Toda K; Department of Neurosurgery, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan; Department of Neurosurgery, National Hospital Organization Nagasaki Kawatana Medical Center, Nagasaki, Japan.
Tanaka S; Department of Pediatrics, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
Baba S; Department of Neurosurgery, Nagasaki University School of Medicine Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yamasaki K; Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
Yatsuhashi H; Nagasaki University School of Medicine Graduate School of Biomedical Sciences, Nagasaki, Japan; Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan.
-
Źródło:
-
Epilepsy & behavior : E&B [Epilepsy Behav] 2021 Apr; Vol. 117, pp. 107799. Date of Electronic Publication: 2021 Feb 18.
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: San Diego, CA : Academic Press, c2000-
-
MeSH Terms:
-
Drug Resistant Epilepsy*/surgery
Pharmaceutical Preparations*
Psychosurgery*
Child ; Child, Preschool ; Corpus Callosum/surgery ; Humans ; Infant ; Retrospective Studies ; Treatment Outcome
-
Contributed Indexing:
-
Keywords: Corpus callosotomy; Developmental outcome; Drug-resistant epilepsy; Infants and young children; Seizure outcome
-
Substance Nomenclature:
-
0 (Pharmaceutical Preparations)
-
Entry Date(s):
-
Date Created: 20210220 Date Completed: 20210420 Latest Revision: 20210420
-
Update Code:
-
20240105
-
DOI:
-
10.1016/j.yebeh.2021.107799
-
PMID:
-
33610103
-
Aim: To examine the developmental and seizure outcomes after corpus callosotomy (CC) in early childhood.
Methods: We retrospectively identified 106 patients who underwent CC for drug-resistant epilepsy before the age of 6 years, at the Nagasaki Medical Center, between July 2002 and July 2016. Patients' developmental outcomes were evaluated one year after CC using the Kinder Infant Development Scale.
Results: The mean preoperative developmental quotient (DQ) was 25.0 (standard deviation [SD], 20.8), and the mean difference between preoperative DQ and one-year postoperative DQ was -1.6 points (SD, 11.6). However, 42.5% of patients had a mean DQ increase of 6.5 points (SD, 6.4), one year after CC from that before surgery. Factors related to the improvement in postoperative DQ were 'low preoperative DQ', 'developmental gain 1 month postoperatively', and 'postoperative seizure-free state'. Approximately 21.7% of patients were seizure-free 1 year after CC.
Interpretation: Performing CC, in infancy and early childhood for patients with drug-resistant epilepsy and severe developmental impairment, was associated with improved development in 42.5% of patients. Remission of seizures, even if only for a short period, contributed to developmental improvement. From a developmental perspective, CC for drug-resistant epilepsy in early childhood is an effective treatment.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
