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Tytuł pozycji:

Clinical and visual outcomes following endogenous endophthalmitis: 175 consecutive cases from a tertiary referral center in Taiwan.

Tytuł:
Clinical and visual outcomes following endogenous endophthalmitis: 175 consecutive cases from a tertiary referral center in Taiwan.
Autorzy:
Kuo G; Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Yen CL; Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Lu YA; Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Chen CY; Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Sun MH; Department of Ophthalmology, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Lin Y; Center for Big Data Analytics and Statistics, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Tian YC; Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
Hsu HH; Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan. Electronic address: .
Źródło:
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2022 Feb; Vol. 55 (1), pp. 114-122. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: Feb. 2010- : Oxford, England : published by Elsevier for the Taiwan Society of Microbiology
Original Publication: Taipei, Taiwan : Chinese Society of Microbiology : Chinese Society of Immunology [and] : Infectious Diseases Society of the Republic of China,
MeSH Terms:
Endophthalmitis*/drug therapy
Endophthalmitis*/epidemiology
Endophthalmitis*/microbiology
Eye Infections, Bacterial*/drug therapy
Eye Infections, Bacterial*/microbiology
Eye Infections, Bacterial*/surgery
Anti-Bacterial Agents/therapeutic use ; Humans ; Retrospective Studies ; Taiwan/epidemiology ; Tertiary Care Centers ; Vitrectomy ; Vitreous Body/microbiology ; Vitreous Body/surgery
Contributed Indexing:
Keywords: Endogenous endophthalmitis; Intravitreous injection; Outcome; Visual acuity; Vitrectomy; Vitreous culture
Substance Nomenclature:
0 (Anti-Bacterial Agents)
Entry Date(s):
Date Created: 20210221 Date Completed: 20220222 Latest Revision: 20220222
Update Code:
20240105
DOI:
10.1016/j.jmii.2021.01.010
PMID:
33610510
Czasopismo naukowe
Background: To elucidate the linkage between organisms and visual outcome in cases of endogenous endophthalmitis.
Methods: Patients who presented with signs of endogenous endophthalmitis between January 2008 and December 2015 and underwent a vitreous tapping were enrolled. The patients' demographics and clinical findings were recorded. The outcomes include visual acuity and enucleation.
Results: A total of 175 consecutive patients with endogenous endophthalmitis were enrolled. Forty-four percent of the patients had a known distal focus of infection. The most common focus was liver abscess (24.6%), and the major intravitreal isolate was Klebsiella pneumoniae (34.4%). In this series, 51.4% of the intravitreal cultures were positive. The visual acuity of fungal ophthalmitis were better than in bacterial ophthalmitis. Multivariate logistic regression showed that Gram negative vitreous isolates, compared with the negative vitreous culture, were associated with higher risk of enucleation (Odds ratio [OR]: 10.424, 95% confidence interval [95% CI]: 3.019-35.995). The use of intravitreal antibiotics, compared non-users, was associated with a reduced risk of enucleation (OR:0.084, 95% CI: 0.026-0.268). Trans pars plana vitrectomy was not associated with risk of enucleation (OR: 0.307, 95% CI: 0.035-2.693). The post-treatment VA was positively correlated with the presenting VA (r = 0.718, p = 0.0001).
Conclusion: Our study demonstrated that liver abscess is the most common source of endogenous endophthalmitis in Taiwan. The visual outcome is good when the presenting visual acuity is relatively well preserved and when the infecting organism is fungus. The use of intra-vitreal antibiotics reduces the risk of enucleation.
Competing Interests: Declaration of competing interest The authors declared no conflict of interests.
(Copyright © 2021. Published by Elsevier B.V.)

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