Comparison of a single high-sensitivity cardiac troponin T measurement with the HEART score for rapid rule-out of acute myocardial infarction in a primary care emergency setting: a cohort study.

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Tytuł:: Comparison of a single high-sensitivity cardiac troponin T measurement with the HEART score for rapid rule-out of acute myocardial infarction in a primary care emergency setting: a cohort study.
Autorzy:: Johannessen TR; Department of General Practice, University of Oslo, Oslo, Norway .; Department of Emergency General Practice, Oslo Accident and Emergency Outpatient Clinic, Oslo, Norway.
Atar D; Department of Cardiolgy, Oslo University Hospital, Ullevaal, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Vallersnes OM; Department of General Practice, University of Oslo, Oslo, Norway.; Department of Emergency General Practice, Oslo Accident and Emergency Outpatient Clinic, Oslo, Norway.
Larstorp ACK; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Section of Cardiovascular and Renal Research, Oslo University Hospital, Ullevaal, Oslo, Norway.
Mdala I; Department of General Practice, University of Oslo, Oslo, Norway.
Halvorsen S; Department of Cardiolgy, Oslo University Hospital, Ullevaal, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Źródło:: BMJ open [BMJ Open] 2021 Feb 24; Vol. 11 (2), pp. e046024. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
MeSH Terms:: Myocardial Infarction*/diagnosis
Troponin T*
Biomarkers ; Cohort Studies ; Electrocardiography ; Emergency Service, Hospital ; Humans ; Norway/epidemiology ; Primary Health Care ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Time Factors ; Troponin
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Contributed Indexing:: Keywords: accident & emergency medicine; coronary heart disease; ischaemic heart disease; myocardial infarction; primary care
Molecular Sequence:: ClinicalTrials.gov NCT02983123
Substance Nomenclature:: 0 (Biomarkers)
0 (Troponin)
0 (Troponin T)
Entry Date(s):: Date Created: 20210225 Date Completed: 20210514 Latest Revision: 20210514
Update Code:: 20240105
PubMed Central ID:: PMC7908281
DOI:: 10.1136/bmjopen-2020-046024
PMID:: 33627355
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Objective: This study aims to compare the rule-out safety of a single high-sensitivity cardiac troponin T (hs-cTnT) with the History, ECG, Age, Risk factors and Troponin (HEART) score in a low-prevalence primary care setting of acute myocardial infarction (AMI).
Participants: Patients with non-specific symptoms suggestive of AMI were consecutively enroled at a primary care emergency clinic in Oslo, Norway from November 2016 to October 2018.
Methods: After initial assessment by a general practitioner, hs-cTnT samples were drawn. AMI was ruled-out by a single hs-cTnT <5 ng/L measured ≥3 hours after symptom onset. The HEART score was calculated retrospectively; a score ≤3 of 10 points was considered low risk. We also calculated a modified HEART score using more sensitive hs-cTnT thresholds. The primary outcome was the diagnostic performance for the rule-out of AMI at the index event; the secondary the composite of AMI or all-cause death at 90 days.
Results: Among 1711 patients, 61 (3.6%) were diagnosed with AMI, and 569 (33.3%) patients were assigned to single rule-out (<5 ng/L). With no AMIs in this group, the negative predictive value (NPV) and sensitivity were both 100.0% (95% CI 99.4% to 100.0% and 94.1% to 100.0%, respectively), and the specificity 34.5% (32.2% to 36.8%). The original HEART score triaged more patients as low risk (n=871), but missed five AMIs (NPV 99.4% (98.7% to 99.8%); sensitivity 91.8% (81.9% to 97.3%) and specificity 52.5% (50.0% to 54.9%)). The modified HEART score increased the low-risk sensitivity to 98.4% (91.2% to 100.0%), with specificity 38.7% (36.3% to 41.1%). The 90-day incidence of AMI or death in the single rule-out and the original and modified low-risk HEART groups were 0.0%, 0.7%, and 0.2%, respectively.
Conclusion: In a primary care emergency setting, a single hs-cTnT strategy was superior to the HEART score in ruling out AMI. This rapid and safe approach may enhance the assessment of patients with chest pain outside of hospitals.
Trial Registration Number: NCT02983123.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

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