Comparison of Carotid Plaque Characteristics Between Men and Women Using Magnetic Resonance Vessel Wall Imaging: A Chinese Atherosclerosis Risk Evaluation Study.

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Tytuł:: Comparison of Carotid Plaque Characteristics Between Men and Women Using Magnetic Resonance Vessel Wall Imaging: A Chinese Atherosclerosis Risk Evaluation Study.
Autorzy:: Zhang L; Medical School of Chinese PLA, Beijing, China.; Department of Radiology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Zhu L; Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1, Zhengzhou, Henan Province, China.
Lu M; Department of Radiology, Pingjin Hospital, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, China.
Zhao X; Center For Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China.
Li F; Operation Department, RIMAG Medical Imaging Corporation, Beijing, China.
Cai J; Department of Radiology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, China.
Yuan C; Department of Radiology, University of Washington, Seattle, USA.
Corporate Authors:: CARE-II investigators
Źródło:: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2021 Aug; Vol. 54 (2), pp. 646-654. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: <2005-> : Hoboken , N.J. : Wiley-Liss
Original Publication: Chicago, IL : Society for Magnetic Resonance Imaging, c1991-
MeSH Terms:: Atherosclerosis*/diagnostic imaging
Atherosclerosis*/epidemiology
Carotid Stenosis*/diagnostic imaging
Carotid Stenosis*/epidemiology
Plaque, Atherosclerotic*/diagnostic imaging
Aged ; Carotid Arteries/diagnostic imaging ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged
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Grant Information:: D171100003017003 Beijing Municipal Science and Technology Commission; Z161100000516194 Beijing Science and technology project; 2017YFC1307904 Ministry of Science and Technology of China; 81771825 National Natural Science Foundation of China; 82001774 National Natural Science Foundation of China
Contributed Indexing:: Keywords: atherosclerosis; carotid artery; magnetic resonance imaging; sex
Entry Date(s):: Date Created: 20210227 Date Completed: 20210722 Latest Revision: 20210722
Update Code:: 20240105
DOI:: 10.1002/jmri.27576
PMID:: 33638575
: Czasopismo naukowe

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Background: Carotid vulnerable plaque is a major cause of stroke and differs between men and women. Few studies have investigated the differences in carotid plaque features between sexes in a Chinese population.
Purpose: To compare carotid atherosclerotic plaque features between men and women in a Chinese population using magnetic resonance imaging.
Study Type: Cross-sectional.
Subjects: A total of 567 patients (mean age: 61.5 ± 10.1 years; 404 men) who had recent stroke or transient ischemia attack and atherosclerotic plaque in at least one carotid artery.
Field Strength: A 3.0 T.
Sequence: T1- and T2-weighted turbo spin echo, three-dimensional time-of-flight (TOF) fast field echo and magnetization-prepared rapid acquisition gradient echo sequences.
Assessment: Plaque characteristics including lumen area (LA), wall area (WA), total vessel area (TVA), mean wall thickness (MWT), and mean normalized wall index (NWI); presence of calcification, lipid-rich necrotic core (LRNC), intraplaque hemorrhage (IPH), and fibrous cap rupture (FCR); and percent composition area (%area) were evaluated and compared between men and women.
Statistical Tests: Independent-sample t test, Mann-Whitney U test, chi-square test, and multiple linear and logistic regressions.
Results: In symptomatic arteries, men had significantly greater LA (46.2 ± 15.6 mm 2 vs. 40.7 ± 12.9 mm 2 , P < 0.05), WA (33.9 ± 11.5 mm 2 vs. 26.3 ± 7.5 mm 2 , P < 0.05), and TVA (80.1 ± 20.4 mm 2 vs. 67.0 ± 18.0 mm 2 , P < 0.05); higher MWT (1.2 ± 0.4 mm vs. 1.0 ± 0.2 mm, P < 0.05); and higher prevalence of LRNC (72.3% vs. 46.0%, P < 0.05) and IPH (18.6% vs. 4.9%, P < 0.05) compared with women. In asymptomatic arteries, men had significantly greater LA (48.3 ± 16.9 mm 2 vs. 42.1 ± 12.6 mm 2 , P < 0.05), WA (32.9 ± 11.0 mm 2 vs. 25.8 ± 6.1 mm 2 , P < 0.05), and TVA (81.2 ± 22.1 mm 2 vs. 67.9 ± 16.5 mm 2 , P < 0.05); higher MWT (1.2 ± 0.3 mm vs. 1.0 ± 0.2 mm, P < 0.05); higher prevalence of LRNC (67.8% vs. 42.9%, P < 0.05), IPH (14.9% vs. 1.2%, P < 0.05), and FCR (6.4% vs. 1.2%, P < 0.05); and higher %LRNC area (24.8 ± 17.2% vs. 17.8 ± 14.1%, P < 0.05) compared with women.
Data Conclusion: Men have similar plaque burden but more vulnerable atherosclerotic plaques compared with women in both symptomatic and asymptomatic carotid arteries in a Chinese population.
Evidence Level: 4 TECHNICAL EFFICACY: Stage 3.
(© 2021 International Society for Magnetic Resonance in Medicine.)

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