Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Metastases can occur in cirrhotic livers with patent portal veins.

Tytuł:
Metastases can occur in cirrhotic livers with patent portal veins.
Autorzy:
Mahdi Z; Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.
Ettel MG; Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
Gonzalez RS; Department of Pathology, Beth Israel Deaconness Medical Center, Boston, MA, USA.
Hart J; Department of Pathology, University of Chicago, Chicago, IL, USA.
Alpert L; Department of Pathology, University of Chicago, Chicago, IL, USA.
Fang J; Department of Pathology, University of Michigan, Faculty Suite Rm. 36-1221-65 2800 Plymouth Rd, Building 35, 48109, Ann Arbor, MI, USA.
Liu N; Department of Pathology, University of Michigan, Faculty Suite Rm. 36-1221-65 2800 Plymouth Rd, Building 35, 48109, Ann Arbor, MI, USA.
Hammer ST; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Panarelli N; Department of Pathology, Montefiore Medical Center, Bronx, NY, USA.
Cheng J; Department of Pathology, University of Michigan, Faculty Suite Rm. 36-1221-65 2800 Plymouth Rd, Building 35, 48109, Ann Arbor, MI, USA.
Greenson JK; Department of Pathology, University of Michigan, Faculty Suite Rm. 36-1221-65 2800 Plymouth Rd, Building 35, 48109, Ann Arbor, MI, USA.
Swanson PE; Department of Pathology, University of Washington, Seattle, WA, USA.
Westerhoff M; Department of Pathology, University of Michigan, Faculty Suite Rm. 36-1221-65 2800 Plymouth Rd, Building 35, 48109, Ann Arbor, MI, USA. .
Źródło:
Diagnostic pathology [Diagn Pathol] 2021 Feb 27; Vol. 16 (1), pp. 18. Date of Electronic Publication: 2021 Feb 27.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: [London] : BioMed Central, 2006-
MeSH Terms:
Fibrosis/*pathology
Liver/*pathology
Neoplasm Metastasis/*pathology
Portal Vein/*pathology
Aged ; Biopsy/methods ; Female ; Humans ; Liver Cirrhosis/pathology ; Male ; Middle Aged
References:
Cancer. 1989 Jul 15;64(2):455-9. (PMID: 2736492)
Experientia. 1983 Nov 15;39(11):1314-5. (PMID: 6641914)
Gut. 2013 Aug;62(8):1169-78. (PMID: 22637699)
Cancer. 1987 May 1;59(9):1547-53. (PMID: 3828954)
Zentralbl Pathol. 1992 Apr;138(2):91-6. (PMID: 1610770)
J Hepatol. 2014 Oct;61(4):912-24. (PMID: 24911462)
J Cancer Res Clin Oncol. 1987;113(1):51-5. (PMID: 3818778)
Hepatogastroenterology. 2003 Sep-Oct;50(53):1490-5. (PMID: 14571771)
Arch Pathol. 1960 Aug;70:226-32. (PMID: 13826067)
Am J Clin Pathol. 1953 Oct;23(10):989-93. (PMID: 13092076)
Am J Pathol. 1942 Jan;18(1):137-40. (PMID: 19970611)
Cancer. 1972 Feb;29(2):435-9. (PMID: 5013543)
Oncotarget. 2016 Aug 23;7(34):55368-55376. (PMID: 27421135)
Jpn J Clin Oncol. 2015 Feb;45(2):160-8. (PMID: 25378650)
N Engl J Med. 1969 Jul 24;281(4):221. (PMID: 5790511)
PLoS One. 2017 Jun 6;12(6):e0178920. (PMID: 28586376)
Cancer Metastasis Rev. 1989 Aug;8(2):98-101. (PMID: 2673568)
Hepatogastroenterology. 2013 Jul-Aug;60(125):1164-8. (PMID: 23803379)
Mol Cancer. 2017 Dec 02;16(1):176. (PMID: 29197379)
Am J Med Sci. 1957 Feb;233(2):145-52. (PMID: 13394591)
Cancer. 1962 Sep-Oct;15:1004-8. (PMID: 14480340)
Cell Death Dis. 2018 Apr 25;9(5):489. (PMID: 29695839)
Br J Cancer. 2016 Jun 28;115(1):34-9. (PMID: 27280634)
J Hepatol. 2012 Sep;57(3):556-63. (PMID: 22617153)
Glycoconj J. 1995 Feb;12(1):1-6. (PMID: 7795408)
Am J Pathol. 1961 Dec;39:739-46. (PMID: 14495098)
PLoS One. 2014 Sep 29;9(9):e108618. (PMID: 25265536)
Contributed Indexing:
Keywords: Cirrhosis; Laennec staging; Liver; Liver mass; Metastases
Entry Date(s):
Date Created: 20210228 Date Completed: 20211104 Latest Revision: 20211104
Update Code:
20240105
PubMed Central ID:
PMC7913426
DOI:
10.1186/s13000-021-01076-5
PMID:
33639984
Czasopismo naukowe
Objectives: Metastases are common in non-cirrhotic livers but are considered unlikely in the setting of cirrhosis. However, the degree of fibrosis in cirrhosis may vary; thus metastases may still access the liver vasculature and present as a mass in cirrhotic livers. This possibility may affect pathologists' diagnostic algorithms when faced with a liver mass biopsy.
Methods: We hypothesized that metastases can occur in cirrhotic livers if fibrous remodeling is not severe or abnormal veno-arterial shunting exists to override an obstructed portal system. We searched departmental archives for cirrhotic livers with masses, categorizing fibrosis by Laennec staging: 4A = mild cirrhosis, 4B = moderate, 4 C = severe.
Results: Of 1453 cirrhotic livers with masses, 1429 were primary tumors and 24 were metastases (1.7 %). Of livers with metastases, most had 4A or 4B cirrhosis by Laennec staging (n = 17; 71 %). Eleven patients were evaluated by ultrasound Doppler; 2 of 5 with Laennec 4 C had reversal of portal vein flow, but all 4A & 4B patients had patent portal veins without reversed flow. Echocardiograms (13 patients) showed no ventricular or atrial septal defects or arteriovenous shunts.
Conclusions: Metastases are uncommon in cirrhotic livers, accounting for 1.7 % of masses. Most involved livers had mild or moderate cirrhosis (Laennec 4A/4B) and patent portal veins; however, as some Laennec 4 C cases also contained metastases, obstructed portal access may not be enough to deter metastatic access.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies