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Tytuł pozycji:

Pneumatosis intestinalis in a radioactive iodine-refractory metastasic thyroid papillary carcinoma with BRAF V600E mutation treated with dabrafenib-trametinib: a case report.

Tytuł:
Pneumatosis intestinalis in a radioactive iodine-refractory metastasic thyroid papillary carcinoma with BRAF mutation treated with dabrafenib-trametinib: a case report.
Autorzy:
Martín-Soberón MC; Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain. .
Ruiz S; Nuclear Medicine Department, University Hospital 12 de Octubre, Madrid, Spain.
De Velasco G; Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain.
Yarza R; Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain.
Carretero A; Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain.
Castellano D; Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain.
Sepúlveda-Sánchez JM; Medical Oncology Department, University Hospital 12 de Octubre, Madrid, Spain.
Źródło:
Journal of medical case reports [J Med Case Rep] 2021 Mar 02; Vol. 15 (1), pp. 109. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji:
Case Reports; Journal Article
Język:
English
Imprint Name(s):
Original Publication: [London] : BioMed Central, [2007-
MeSH Terms:
Emphysema/*diagnostic imaging
Imidazoles/*adverse effects
Intestinal Diseases/*diagnostic imaging
Oximes/*adverse effects
Protein Kinase Inhibitors/*adverse effects
Pyridones/*adverse effects
Pyrimidinones/*adverse effects
Skull Base Neoplasms/*drug therapy
Thyroid Cancer, Papillary/*drug therapy
Thyroid Neoplasms/*pathology
Emphysema/chemically induced ; Female ; Humans ; Intestinal Diseases/chemically induced ; Iodine Radioisotopes/therapeutic use ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Proto-Oncogene Proteins B-raf/genetics ; Skull Base Neoplasms/diagnostic imaging ; Skull Base Neoplasms/genetics ; Skull Base Neoplasms/secondary ; Thyroid Cancer, Papillary/diagnostic imaging ; Thyroid Cancer, Papillary/genetics ; Thyroid Cancer, Papillary/secondary
References:
Klin Onkol. 2018 Fall;31(5):339-344. (PMID: 30541319)
Int J Surg Case Rep. 2018;53:214-217. (PMID: 30428434)
Br J Clin Pharmacol. 2015 Oct;80(4):765-7. (PMID: 25847075)
AMA Arch Pathol. 1952 Jun;53(6):523-49. (PMID: 14923068)
Gastroenterol Hepatol. 2016 Dec;39(10):672-673. (PMID: 26547612)
N Engl J Med. 2015 Jan 1;372(1):30-9. (PMID: 25399551)
Dis Colon Rectum. 1976 Mar;19(2):107-11. (PMID: 176016)
Radiographics. 2000 Sep-Oct;20(5):1213-24; discussion 1224-6. (PMID: 10992012)
J Clin Endocrinol Metab. 2006 Aug;91(8):2892-9. (PMID: 16684830)
AJR Am J Roentgenol. 2012 Dec;199(6):1259-65. (PMID: 23169717)
Contributed Indexing:
Keywords: Case report; Dabrafenib; Pneumatosis intestinalis (PI); Targeted therapies; Thyroid cancer; Trametinib
Substance Nomenclature:
0 (Imidazoles)
0 (Iodine Radioisotopes)
0 (Oximes)
0 (Protein Kinase Inhibitors)
0 (Pyridones)
0 (Pyrimidinones)
33E86K87QN (trametinib)
EC 2.7.11.1 (BRAF protein, human)
EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
QGP4HA4G1B (dabrafenib)
Entry Date(s):
Date Created: 20210303 Date Completed: 20210315 Latest Revision: 20210315
Update Code:
20240105
PubMed Central ID:
PMC7927265
DOI:
10.1186/s13256-020-02581-9
PMID:
33653337
Czasopismo naukowe
Background: Pneumatosis intestinalis (PI) is a rare entity which refers to the presence of gas within the wall of the small bowel or colon which is a radiographic sign. The etiology and clinical presentation are variable. Patients with PI may present either with chronic mild non-specific symptoms or with acute abdominal pain with peritonitis. Some cases of intestinal pneumatosis have been reported as adverse events of new oncological treatments such as targeted therapies that are widely used in multiple tumors.
Case Presentation: A 59-year-old caucasian female with radioactive iodine-refractory metastatic thyroid papillary carcinoma with BRAF V600E mutation was treated with dabrafenib and trametinib as a compassionate use. After 4 months treatment, positron emission tomography-computed tomography (PET-CT) showed PI. At the time of diagnosis, the patient was asymptomatic without signs of peritonitis. The initial treatment was conservative and no specific treatment for PI was needed. Unfortunately, after dabrafenib-trametinib withdrawal, the patient developed tumor progression with significant clinical worsening.
Conclusions: This case report is, in our knowledge, the first description of PI in a patient treated with dabrafenib-trametinib. Conservative treatment is feasible if there are no abdominal symptoms.
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