FOS Rearrangement and Expression in Cementoblastoma.

Szczegóły
Abstrakt

Tytuł:: FOS Rearrangement and Expression in Cementoblastoma.
Autorzy:: Lam SW; Departments of Pathology.
Cleven AHG; Departments of Pathology.
Briaire-de Bruijn IH; Departments of Pathology.
Schreuder WH; Department of Oral and Maxillofacial Surgery/Head and Neck Surgery, Amsterdam University Medical Center/Antoni van Leeuwenhoek Hospital.
Kroon HM; Radiology.
Savci-Heijink DC; Department of Pathology, Academic Medical Center, Amsterdam.
Suurmeijer AJH; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Szuhai K; Cell and Chemical Biology, Leiden University Medical Center, Leiden.
Bovée JVMG; Departments of Pathology.
Baumhoer D; Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Źródło:: The American journal of surgical pathology [Am J Surg Pathol] 2021 May 01; Vol. 45 (5), pp. 690-693.
Typ publikacji:: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
Original Publication: New York, Masson.
MeSH Terms:: Biomarkers, Tumor*/analysis
Biomarkers, Tumor*/genetics
Bone Neoplasms*/chemistry
Bone Neoplasms*/genetics
Bone Neoplasms*/pathology
Dental Cementum*/chemistry
Dental Cementum*/pathology
Gene Rearrangement*
Odontogenic Tumors*/chemistry
Odontogenic Tumors*/genetics
Odontogenic Tumors*/pathology
Osteoblastoma*/chemistry
Osteoblastoma*/genetics
Osteoblastoma*/pathology
Proto-Oncogene Proteins c-fos*/analysis
Proto-Oncogene Proteins c-fos*/genetics
Tooth Root*/chemistry
Tooth Root*/pathology
Adolescent ; Adult ; Child ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Male ; Middle Aged ; Netherlands ; Switzerland ; Young Adult
References:: Slootweg PJ. Cementoblastoma and osteoblastoma: a comparison of histologic features. J Oral Pathol Med. 1992;21:385–389.
Chrcanovic BR, Gomez RS. Cementoblastoma: an updated analysis of 258 cases reported in the literature. J Craniomaxillofac Surg. 2017;45:1759–1766.
Fittall MW, Mifsud W, Pillay N, et al. Recurrent rearrangements of FOS and FOSB define osteoblastoma. Nat Commun. 2018;9:2150.
Lam SW, Cleven AHG, Kroon HM, et al. Utility of FOS as diagnostic marker for osteoid osteoma and osteoblastoma. Virchows Arch. 2020;476:455–463.
Amary F, Markert E, Berisha F, et al. FOS expression in osteoid osteoma and osteoblastoma: a valuable ancillary diagnostic tool. Am J Surg Pathol. 2019;43:1661–1667.
Ulmansky M, Hjorting-Hansen E, Praetorius F, et al. Benign cementoblastoma. A review and five new cases. Oral Surg Oral Med Oral Pathol. 1994;77:48–55.
El-Naggar AK, Chan JKC, Grandis JR, et al. WHO Classification of Head and Neck Tumours. Lyon, France: International Agency for Research on Cancer (IARC); 2017.
Slootweg P. Pathology of the Maxillofacial Bones: A Guide to Diagnosis. Cham, Switzerland: Springer International Publishing; 2015:5–6.
Milde-Langosch K. The Fos family of transcription factors and their role in tumourigenesis. Eur J Cancer. 2005;41:2449–2461.
Bozec A, Bakiri L, Jimenez M, et al. Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production. J Cell Biol. 2010;190:1093–1106.
Agaram NP, Zhang L, Cotzia P, et al. Expanding the spectrum of genetic alterations in pseudomyogenic hemangioendothelioma with recurrent novel ACTB-FOSB gene fusions. Am J Surg Pathol. 2018;42:1653–1661.
Huang SC, Zhang L, Sung YS, et al. Frequent FOS gene rearrangements in epithelioid hemangioma: a molecular study of 58 cases with morphologic reappraisal. Am J Surg Pathol. 2015;39:1313–1321.
Antonescu CR, Chen HW, Zhang L, et al. ZFP36-FOSB fusion defines a subset of epithelioid hemangioma with atypical features. Genes Chromosomes Cancer. 2014;53:951–959.
van Ijzendoorn DG, de Jong D, Romagosa C, et al. Fusion events lead to truncation of FOS in epithelioid hemangioma of bone. Genes Chromosomes Cancer. 2015;54:565–574.
Substance Nomenclature:: 0 (Biomarkers, Tumor)
0 (FOS protein, human)
0 (Proto-Oncogene Proteins c-fos)
Entry Date(s):: Date Created: 20210303 Date Completed: 20210510 Latest Revision: 20210510
Update Code:: 20240105
DOI:: 10.1097/PAS.0000000000001695
PMID:: 33653978
: Czasopismo naukowe

Cementoblastomas are rare odontogenic tumors developing in close proximity to the roots of teeth. Due to their striking morphologic resemblance to osteoblastomas of the peripheral skeleton, we set out to determine whether cementoblastomas harbor the same FOS rearrangements with overexpression of c-FOS as has recently been described for osteoblastomas. In total, 16 cementoblastomas were analyzed for FOS expression by immunohistochemistry and for FOS rearrangements by fluorescence in situ hybridization (FISH). We observed strong and diffuse staining of c-FOS in 71% of cementoblastomas and identified a FOS rearrangement in all cases (n=3) applicable for FISH. In the remaining cases, FISH failed due to decalcification. Cementoblastomas harbor similar FOS rearrangements and show overexpression of c-FOS like osteoblastomas, suggesting that both entities might represent parts of the spectrum of the same disease.
Competing Interests: Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.
(Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

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