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Tytuł pozycji:

Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long-term prospective follow-up study.

Tytuł:
Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long-term prospective follow-up study.
Autorzy:
Kodama M; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.; Faculty of Welfare and Health Science, Oita University, Oita, Japan.
Okimoto T; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Mizukami K; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Hirashita Y; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Wada Y; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Fukuda M; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Matsunari O; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Okamoto K; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Ogawa R; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Fukuda K; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Kudo Y; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Kawahara Y; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Murakami K; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
Źródło:
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2021 Aug; Vol. 36 (8), pp. 2210-2216. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Melbourne ; Boston : Blackwell Scientific Publications, c1986-
MeSH Terms:
Gastric Mucosa*/drug effects
Gastric Mucosa*/pathology
Helicobacter Infections*/diagnosis
Helicobacter Infections*/drug therapy
Helicobacter Infections*/pathology
Helicobacter pylori*/isolation & purification
Anti-Bacterial Agents/*administration & dosage
Proton Pump Inhibitors/*administration & dosage
Adult ; Aged ; Amoxicillin/administration & dosage ; Atrophy/drug therapy ; Atrophy/pathology ; Clarithromycin/administration & dosage ; Female ; Follow-Up Studies ; Gastritis, Atrophic/drug therapy ; Gastritis, Atrophic/pathology ; Humans ; Lansoprazole/administration & dosage ; Male ; Metaplasia/drug therapy ; Metaplasia/pathology ; Metronidazole/administration & dosage ; Middle Aged ; Omeprazole/administration & dosage ; Prospective Studies ; Rabeprazole/administration & dosage ; Sex Factors ; Young Adult
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Grant Information:
18 K07946 JSPS KAKENHI
Contributed Indexing:
Keywords: Atrophic gastritis; Eradication; Gastric cancer; Helicobacter pylori; Intestinal metaplasia
Substance Nomenclature:
0 (Anti-Bacterial Agents)
0 (Proton Pump Inhibitors)
0K5C5T2QPG (Lansoprazole)
140QMO216E (Metronidazole)
32828355LL (Rabeprazole)
804826J2HU (Amoxicillin)
H1250JIK0A (Clarithromycin)
KG60484QX9 (Omeprazole)
Entry Date(s):
Date Created: 20210303 Date Completed: 20220202 Latest Revision: 20220202
Update Code:
20240105
DOI:
10.1111/jgh.15477
PMID:
33656793
Czasopismo naukowe
Background and Aim: Improvement of atrophic gastritis and intestinal metaplasia (IM) is considered to reduce the gastric cancer risk, but whether it can be achieved by H. pylori eradication (HPE) remains controversial. To evaluate the effect of HPE, we observed the gastric mucosa for up to17 years after HPE and sex differences in gastric mucosa.
Methods: In total, 172 patients (94 males, 78 females) with HPE were enrolled. Annual histological evaluations were performed for up to 17 years. The grades of mononuclear cells, neutrophils, atrophy, IM in the antrum and corpus were evaluated using the updated Sydney system.
Results: Relative to the pre-HPE period, atrophy had improved significantly 1 year after HPE in the antrum (1.50 ± 0.75 vs. 1.21 ± 1.25, P < 0.01) and corpus (0.59 ± 0.75 vs. 0.18 ± 0.52, P < 0.05). IM showed no significant change during 17 years after HPE at either biopsy site. Atrophy scores did not differ significantly between males and females. IM scores were significantly higher in males than in females before eradication (antrum, 0.67 ± 0.94 vs. 0.44 ± 0.77, P = 0.003, corpus, 0.20 ± 0.62 vs. 0.047 ± 0.21, P = 0.0027) and at most observation timepoints.
Conclusions: During 17 years after HPE, atrophy, but not IM, improved significantly at the greater curvatures of the antrum and corpus. IM was significantly more severe in males than in females. Careful follow-up after HPE based on sex differences in gastric mucosal characteristics is important.
(© 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)

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