Effect of Selected Anionic and Cationic Drugs Affecting the Central Nervous System on Electrical Properties of Phosphatidylcholine Liposomes: Experiment and Theory.

Szczegóły
Abstrakt

Tytuł:: Effect of Selected Anionic and Cationic Drugs Affecting the Central Nervous System on Electrical Properties of Phosphatidylcholine Liposomes: Experiment and Theory.
Autorzy:: Kotyńska J; Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciolkowskiego 1K, 15-245 Bialystok, Poland.
Naumowicz M; Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciolkowskiego 1K, 15-245 Bialystok, Poland.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 25; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 25.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:: Electricity*
Barbiturates/*pharmacology
Central Nervous System/*physiology
Perphenazine/*pharmacology
Phosphatidylcholines/*metabolism
Animals ; Anions ; Cations ; Central Nervous System/drug effects ; Chickens ; Isoelectric Point ; Liposomes ; Membranes, Artificial ; Models, Biological ; Scattering, Radiation ; Solutions ; Static Electricity
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Contributed Indexing:: Keywords: adsorption equilibria; barbituric acid; charged drugs; electrophoretic light scattering; liposomes; pH; perphenazine; surface charge
Substance Nomenclature:: 0 (Anions)
0 (Barbiturates)
0 (Cations)
0 (Liposomes)
0 (Membranes, Artificial)
0 (Phosphatidylcholines)
0 (Solutions)
FTA7XXY4EZ (Perphenazine)
WQ92Y2793G (barbituric acid)
Entry Date(s):: Date Created: 20210306 Date Completed: 20210416 Latest Revision: 20210416
Update Code:: 20240104
PubMed Central ID:: PMC7956533
DOI:: 10.3390/ijms22052270
PMID:: 33668791
: Czasopismo naukowe

Pełny tekst

Interactions between phospholipid membranes and selected drugs affecting the central nervous system (CNS) were investigated. Small, unilamellar liposomes were used as biomimetic cell membrane models. Microelectrophoretic experiments on two-component liposomes were performed using the electrophoretic light scattering technique (ELS). The effect of both positively (perphenazine, PF) and negatively (barbituric acid, BA) charged drugs on zwitterionic L-α-phosphatidylcholine (PC) membranes were analyzed. Experimental membrane surface charge density (δ) data were determined as a function of pH. Quantitative descriptions of the adsorption equilibria formed due to the binding of solution ions to analyzed two-component membranes are presented. Binding constants of the solution ions with perphenazine and barbituric acid-modified membranes were determined. The results of our research show that both charged drugs change surface charge density values of phosphatidylcholine membranes. It can be concluded that perphenazine and barbituric acid are located near the membrane surface, interacting electrostatically with phosphatidylcholine polar heads.

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