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Tytuł pozycji:

Comparison of static and dynamic mode in the electrochemical oxidation of fesoterodine with the use of experimental design approach.

Tytuł :
Comparison of static and dynamic mode in the electrochemical oxidation of fesoterodine with the use of experimental design approach.
Autorzy :
Bartosińska E; Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, Prague, 12843, Czech Republic.
Kozlík P; Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, Prague, 12843, Czech Republic.
Kubíčková A; Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, Prague, 12843, Czech Republic.
Heřt J; Zentiva, K.s. U Kabelovny 130, 102 37, Prague, Czech Republic.
Fischer J; Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, Prague, 12843, Czech Republic.
Křížek T; Charles University, Faculty of Science, Department of Analytical Chemistry, Albertov 6, Prague, 12843, Czech Republic. Electronic address: .
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Źródło :
Talanta [Talanta] 2021 May 01; Vol. 226, pp. 122141. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Amsterdam : Elsevier
Original Publication: Oxford : Pergamon Press
MeSH Terms :
Electrolysis*
Research Design*
Benzhydryl Compounds ; Electrochemical Techniques ; Electrodes ; Oxidation-Reduction
Contributed Indexing :
Keywords: Electrochemical oxidation; Fesoterodine fumarate; Flow cells; Pharmaceutical degradation studies
Substance Nomenclature :
0 (Benzhydryl Compounds)
621G617227 (fesoterodine)
Entry Date(s) :
Date Created: 20210307 Date Completed: 20210514 Latest Revision: 20210514
Update Code :
20210515
DOI :
10.1016/j.talanta.2021.122141
PMID :
33676692
Czasopismo naukowe
Electrochemical conversion of fesoterodine to one of its oxidation products was evaluated with the application of the wall-jet flow cell. A traditional, "static" mode of electrolysis was compared with the "dynamic" mode of cell performance. For statistical assessment of the data, experiments were planned and performed with the application of design of experiments approach, namely Taguchi L18 design. After screening phase, the experimental settings were broadened or adjusted according to the results and optimization was performed. All of the samples were electrolysed with the use of chronoamperometric method in a three electrode system. The electrolysed samples were analysed using UHPLC-PDA-QDA method. The chromatographic run was performed in gradient elution with the application of C8 column. The response was expressed as % area of the main peak found with the PDA detection method whereas QDA detector was used in positive SIM mode for structural confirmation. All data obtained for both screening and optimization were treated together and linear models were adjusted. The use of large-surface glassy carbon electrode along with pH~7 were found to be the most significant factors influencing electrochemical oxidation of fesoterodine in both modes. The major differences were identified in terms of voltage applied to the electrodes which yielded the highest amounts of oxidation product. Evolution of electrochemical methods may serve as complementary technique in stress degradation studies in pharmaceutical industry.
(Copyright © 2021 Elsevier B.V. All rights reserved.)

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