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Tytuł:
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Evaluation of genotoxic damage in buccal mucosa cytome assays in Iraqi school children exposed to air pollutants emanating from oil fields.
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Autorzy:
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Sabah JT; Faculty of Sciences, Wasit University, Iraq. Electronic address: .
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Źródło:
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Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2021 Mar-Apr; Vol. 863-864, pp. 503304. Date of Electronic Publication: 2020 Dec 25.
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Typ publikacji:
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Clinical Trial; Journal Article; Multicenter Study
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier, 1997-
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MeSH Terms:
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Cell Nucleus*
DNA Damage*
Mouth Mucosa*
Oil and Gas Fields*
Air Pollutants/*toxicity
Child ; Female ; Humans ; Male ; Micronucleus Tests ; Schools
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Contributed Indexing:
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Keywords: Cytome assay; Exfoliated buccal cells; Genotoxicity; Micronuclei; Nuclear anomalies; Oil fields
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Substance Nomenclature:
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0 (Air Pollutants)
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Entry Date(s):
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Date Created: 20210308 Date Completed: 20210406 Latest Revision: 20210920
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Update Code:
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20240104
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DOI:
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10.1016/j.mrgentox.2020.503304
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PMID:
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33678241
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Presently, over 135 thousand barrels of crude oil are extracted daily from the Al-ahdeb oil fields (situated at 180 km south east of Baghdad, Iraq). Millions of gallons of untreated toxic wastes, gas and crude oil are released into the environment. Oil mining mediated pollution may cause damage to humans and the environment. To investigate potential health risks for children living in this area, we recruited a sample of 6-8 year old school children residing within a 5 km radius around the oil field, and a control sample of children of the same age from a school 40 km away from the oil-field. Exfoliated buccal mucosa cells obtained from these children were analyzed applying the micronucleus (MN) cytome assay. Possible confounding variables such as x-rays performed during three weeks preceding sampling were obtained by a questionnaire. Nuclear anomalies were significantly elevated in children living near the oil-field. Micronucleated cells 1.3-fold, nuclear buds 3-folds, binucleated cells 3-folds, karyorrhetic cells 4-folds and karyolysis more than 10 folds with a significant difference (P < 0.05). Hence, children living in the proximity of Iraqi oil-fields are at elevated risk of genetic damage, which can cause detrimental health effects in the future.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
