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Tytuł pozycji:

The intermediary role of adolescent temperamental and behavioral traits on the prospective associations between polygenic risk and cannabis use among young adults of European Ancestry.

Tytuł:
The intermediary role of adolescent temperamental and behavioral traits on the prospective associations between polygenic risk and cannabis use among young adults of European Ancestry.
Autorzy:
Brick LA; Behavioral Genetics of Addiction Laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
Benca-Bachman CE; Behavioral Genetics of Addiction Laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
Bertin L; Behavioral Genetics of Addiction Laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
Martin KP; Behavioral Genetics of Addiction Laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
Risner V; Behavioral Genetics of Addiction Laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
Palmer RHC; Behavioral Genetics of Addiction Laboratory, Department of Psychology at Emory University, Atlanta, GA, USA.
Źródło:
Addiction (Abingdon, England) [Addiction] 2021 Oct; Vol. 116 (10), pp. 2779-2789. Date of Electronic Publication: 2021 Apr 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Język:
English
Imprint Name(s):
Publication: Oxford : Wiley-Blackwell
Original Publication: Abingdon, Oxfordshire, UK : Carfax Pub. Co., c1993-
MeSH Terms:
Cannabis*
Adolescent ; Adult ; Anxiety Disorders ; Child ; Genome-Wide Association Study ; Humans ; Multifactorial Inheritance/genetics ; Risk Factors ; Young Adult
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Grant Information:
DP1 DA042103 United States DA NIDA NIH HHS; R01 DA042742 United States DA NIDA NIH HHS
Contributed Indexing:
Keywords: Adolescence; cannabis use; externalizing; heritability; polygenic risk; young adult
Entry Date(s):
Date Created: 20210309 Date Completed: 20210929 Latest Revision: 20221003
Update Code:
20240105
PubMed Central ID:
PMC8426427
DOI:
10.1111/add.15476
PMID:
33686717
Czasopismo naukowe
Background and Aims: Cannabis use (CU) is an etiologically complex behavior with several social, temperamental, neurocognitive, and behavioral precursors. Biometrical and molecular studies suggest an interplay of environmental and pleiotropic influences. However, it remains unclear whether identified genetic effects related to behavioral and temperamental characteristics have developmentally direct or indirect mechanisms on CU behavior. The Transmissible Liability Index (TLI) is a measure of continuous liability based on developmental precursors of substance use disorders. This study aimed to examine if the TLI plays a role in understanding genetic risk for CU behaviors.
Design: Genome-wide association studies (n > 10 000; European Ancestry [EA]) of CU, risk tolerance, neuroticism, anxiety, and depression were used to construct polygenic scores (PGSs). Analyses assessed whether PGSs indirectly impacted risk for repeated use via TLI.
Setting: United States of America.
Participants: From Add Health study, 4077 individuals of EA age 11 to 21 during baseline interview collection.
Measurements: Outcomes were initiation and repeated cannabis use (>5× in lifetime). The TLI was parameterized using a latent factor from 21 questions assessing for precursors of disordered use.
Findings: The marker-based heritability of TLI, initiation, and repeated use were significant, but modest (14%, P = 0.033; 15%, P = 0.025; and 17%, P = 0.008, respectively). TLI and repeated use were genetically correlated (r g  = 0.76, P = 0.033). The PGS for CU was associated with increased risk for repeated use and PGS for risk tolerance and depression were associated with TLI. Mediation analyses indicated significant, but very weak, indirect effects of PGS for risk tolerance and depression on repeated CU via the TLI.
Conclusions: Adolescent behavioral and temperamental characteristics (i.e. the Transmissible Liability Index) appear to be early indicators of repeated cannabis use in adulthood. Although polygenic scores for cannabis use directly increased risk for repeated cannabis use, weak evidence was found for the role of polygenic scores of other internalizing/externalizing traits acting through adolescent derived Transmissible Liability Index on cannabis use behavior.
(© 2021 Society for the Study of Addiction.)

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