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Tytuł:
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Screening of lipid metabolism biomarkers in patients with coronary heart disease via ultra-performance liquid chromatography-high resolution mass spectrometry.
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Autorzy:
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Cai F; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Ren F; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Zhang Y; Department of Cardiology, Yunnan First People's Hospital, Kunming 650032, China.
Ding X; Department of Cardiology, Yunnan First People's Hospital, Kunming 650032, China.
Fu G; School of Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Ren D; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Yang L; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Chen N; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Shang Y; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Hu Y; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China.
Yi L; Faculty of Agriculture and Food Science, Kunming University of Science and Technology, Yunnan, Kunming 650500, China. Electronic address: .
Zhang H; Department of Cardiology, Yunnan First People's Hospital, Kunming 650032, China. Electronic address: .
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Źródło:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2021 Apr 15; Vol. 1169, pp. 122603. Date of Electronic Publication: 2021 Feb 23.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam ; New York : Elsevier, c2002-
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MeSH Terms:
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Glycerophospholipids*/blood
Glycerophospholipids*/metabolism
Sphingolipids*/blood
Sphingolipids*/metabolism
Chromatography, High Pressure Liquid/*methods
Coronary Disease/*metabolism
Lipid Metabolism/*physiology
Aged ; Biomarkers/blood ; Biomarkers/metabolism ; Case-Control Studies ; Female ; High-Throughput Screening Assays ; Humans ; Lipidomics ; Male ; Mass Spectrometry/methods ; Middle Aged
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Contributed Indexing:
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Keywords: Biomarkers; Coronary heart disease; Integrated filtering strategy; Lipid metabolites; Mass spectrometry
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Substance Nomenclature:
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0 (Biomarkers)
0 (Glycerophospholipids)
0 (Sphingolipids)
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Entry Date(s):
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Date Created: 20210310 Date Completed: 20210528 Latest Revision: 20210528
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Update Code:
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20240105
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DOI:
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10.1016/j.jchromb.2021.122603
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PMID:
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33690078
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Coronary heart disease (CHD) has a high mortality worldwide. This study aimed to screen lipid metabolism biomarkers in patients with coronary heart disease via ultra-performance liquid chromatography-high resolution mass spectrometry. Extraction and reconstitution solvents, liquid chromatographic and mass spectrometry conditions were optimized to detect more plasma lipid metabolites. In this study, the chromatographic and mass spectra characteristics of lipid metabolites were summarized. A total of 316 lipid metabolites were annotated via diagnostic fragment ion filtration, nitrogen rule filtration, and neutral loss filtration. Glycerophospholipid metabolism and sphingolipid metabolism were revealed as the main lipid disorders of CHD. This study provides a novel insight for high-throughput detection of lipid metabolites in plasma and provides a further understanding of the occurrence of CHD, which can provide valuable suggestions for the prevention of CHD.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
