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Tytuł:
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Anthocyanins from the fruits of Lycium ruthenicum Murray improve high-fat diet-induced insulin resistance by ameliorating inflammation and oxidative stress in mice.
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Autorzy:
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Tian B; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. , Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, P. R. China. , Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, P. R. China.
Zhao J; Institute of Wolfberry Engineering Technology Research, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, P. R. China. , Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, P. R. China.
Xie X; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
Chen T; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
Yin Y; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
Zhai R; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
Wang X; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
An W; Institute of Wolfberry Engineering Technology Research, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, P. R. China. , Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, P. R. China.
Li J; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
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Źródło:
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Food & function [Food Funct] 2021 May 11; Vol. 12 (9), pp. 3855-3871.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Cambridge : Royal Society of Chemistry
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MeSH Terms:
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Dietary Supplements*
Insulin Resistance*
Lycium*
Anthocyanins/*administration & dosage
Diet, High-Fat/*adverse effects
Animals ; Blood Glucose/metabolism ; Fruit/chemistry ; Gluconeogenesis ; Homeostasis ; Inflammation ; Insulin Receptor Substrate Proteins/metabolism ; Lipid Metabolism ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Obesity/prevention & control ; Oxidative Stress ; Signal Transduction ; Toll-Like Receptor 4/metabolism
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Substance Nomenclature:
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0 (Anthocyanins)
0 (Blood Glucose)
0 (Insulin Receptor Substrate Proteins)
0 (Irs1 protein, mouse)
0 (NF-kappa B)
0 (Tlr4 protein, mouse)
0 (Toll-Like Receptor 4)
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Entry Date(s):
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Date Created: 20210311 Date Completed: 20210607 Latest Revision: 20210701
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Update Code:
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20240104
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DOI:
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10.1039/d0fo02936j
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PMID:
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33704297
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A high-fat diet (HFD) promotes tissue inflammation, oxidative stress and insulin resistance (IR), thereby contributing to the development of obesity and diabetes. Anthocyanins from Lycium ruthenicum (AC) have demonstrated anti-obesity effects and modulated IR. To investigate the mechanism by which AC attenuates the adverse effects of consuming a HFD, C57BL/6J mice were fed a HFD supplemented with AC or a control diet without AC for 12 weeks. AC supplementation decreased the amount of weight gain, hepatic lipid, and sequentially improved dyslipidemia, inflammation, oxidative stress, and IR in HFD-fed mice. Molecular data revealed that AC inhibited hepatic inflammation by reducing TLR4/NF-κB/JNK in the liver tissues and ameliorated oxidative stress by activating the Nrf2/HO-1/NQO1 pathway. Thus, AC might activate IRS-1/AKT and prevent HFD-induced gluconeogenesis and IR by ameliorating inflammation and oxidative stress. Modulation of inflammation and oxidative stress with AC may represent a promising target for the treatment of IR and provide insight into the mechanism by which AC protects against obesity.
Erratum in: Food Funct. 2021 Aug 2;12(15):7092. (PMID: 34195733)