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Tytuł pozycji:

Anthocyanins from the fruits of Lycium ruthenicum Murray improve high-fat diet-induced insulin resistance by ameliorating inflammation and oxidative stress in mice.

Tytuł:
Anthocyanins from the fruits of Lycium ruthenicum Murray improve high-fat diet-induced insulin resistance by ameliorating inflammation and oxidative stress in mice.
Autorzy:
Tian B; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. , Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, P. R. China. , Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, P. R. China.
Zhao J; Institute of Wolfberry Engineering Technology Research, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, P. R. China. , Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, P. R. China.
Xie X; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
Chen T; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
Yin Y; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
Zhai R; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
Wang X; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
An W; Institute of Wolfberry Engineering Technology Research, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, P. R. China. , Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan, P. R. China.
Li J; College of Food Science and Engineering, Northwest A&F University, Yangling, P. R. China. .
Źródło:
Food & function [Food Funct] 2021 May 11; Vol. 12 (9), pp. 3855-3871.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Cambridge : Royal Society of Chemistry
MeSH Terms:
Dietary Supplements*
Insulin Resistance*
Lycium*
Anthocyanins/*administration & dosage
Diet, High-Fat/*adverse effects
Animals ; Blood Glucose/metabolism ; Fruit/chemistry ; Gluconeogenesis ; Homeostasis ; Inflammation ; Insulin Receptor Substrate Proteins/metabolism ; Lipid Metabolism ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Obesity/prevention & control ; Oxidative Stress ; Signal Transduction ; Toll-Like Receptor 4/metabolism
Substance Nomenclature:
0 (Anthocyanins)
0 (Blood Glucose)
0 (Insulin Receptor Substrate Proteins)
0 (Irs1 protein, mouse)
0 (NF-kappa B)
0 (Tlr4 protein, mouse)
0 (Toll-Like Receptor 4)
Entry Date(s):
Date Created: 20210311 Date Completed: 20210607 Latest Revision: 20210701
Update Code:
20240104
DOI:
10.1039/d0fo02936j
PMID:
33704297
Czasopismo naukowe
A high-fat diet (HFD) promotes tissue inflammation, oxidative stress and insulin resistance (IR), thereby contributing to the development of obesity and diabetes. Anthocyanins from Lycium ruthenicum (AC) have demonstrated anti-obesity effects and modulated IR. To investigate the mechanism by which AC attenuates the adverse effects of consuming a HFD, C57BL/6J mice were fed a HFD supplemented with AC or a control diet without AC for 12 weeks. AC supplementation decreased the amount of weight gain, hepatic lipid, and sequentially improved dyslipidemia, inflammation, oxidative stress, and IR in HFD-fed mice. Molecular data revealed that AC inhibited hepatic inflammation by reducing TLR4/NF-κB/JNK in the liver tissues and ameliorated oxidative stress by activating the Nrf2/HO-1/NQO1 pathway. Thus, AC might activate IRS-1/AKT and prevent HFD-induced gluconeogenesis and IR by ameliorating inflammation and oxidative stress. Modulation of inflammation and oxidative stress with AC may represent a promising target for the treatment of IR and provide insight into the mechanism by which AC protects against obesity.
Erratum in: Food Funct. 2021 Aug 2;12(15):7092. (PMID: 34195733)

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