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Tytuł pozycji:

Depression and increased risk of non-alcoholic fatty liver disease in individuals with obesity.

Tytuł :
Depression and increased risk of non-alcoholic fatty liver disease in individuals with obesity.
Autorzy :
Cho IY; Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Chang Y; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.
Sung E; Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Kang JH; Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Wild SH; Usher Institute University of Edinburgh, Edinburgh, UK.
Byrne CD; Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, UK.; National Institute for Health Research Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
Shin H; Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Ryu S; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.
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Źródło :
Epidemiology and psychiatric sciences [Epidemiol Psychiatr Sci] 2021 Mar 12; Vol. 30, pp. e23. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Cambridge : Cambridge University Press
MeSH Terms :
Depression/*epidemiology
Liver Cirrhosis/*epidemiology
Non-alcoholic Fatty Liver Disease/*epidemiology
Obesity/*complications
Adult ; Cohort Studies ; Fatty Liver ; Female ; Humans ; Liver Cirrhosis/psychology ; Male ; Non-alcoholic Fatty Liver Disease/psychology ; Obesity/epidemiology ; Risk Factors
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Contributed Indexing :
Keywords: Depression; hepatic fibrosis; hepatic steatosis; non-alcoholic fatty liver disease; obesity
Entry Date(s) :
Date Created: 20210312 Date Completed: 20210316 Latest Revision: 20210507
Update Code :
20210507
PubMed Central ID :
PMC8061301
DOI :
10.1017/S204579602000116X
PMID :
33706839
Czasopismo naukowe
Abstract.
Aims: The longitudinal relationship between depression and the risk of non-alcoholic fatty liver disease is uncertain. We examined: (a) the association between depressive symptoms and incident hepatic steatosis (HS), both with and without liver fibrosis; and (b) the influence of obesity on this association.
Methods: A cohort of 142 005 Korean adults with neither HS nor excessive alcohol consumption at baseline were followed for up to 8.9 years. The validated Center for Epidemiologic Studies-Depression score (CES-D) was assessed at baseline, and subjects were categorised as non-depressed (a CES-D < 8, reference) or depression (CES-D ⩾ 16). HS was diagnosed by ultrasonography. Liver fibrosis was assessed by the fibrosis-4 index (FIB-4). Parametric proportional hazards models were used to estimate the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs).
Results: During a median follow-up of 4.0 years, 27 810 people with incident HS and 134 with incident HS plus high FIB-4 were identified. Compared with the non-depressed category, the aHR (95% CIs) for incident HS was 1.24 (1.15-1.34) for CES-D ⩾ 16 among obese individuals, and 1.00 (0.95-1.05) for CES-D ⩾ 16 among non-obese individuals (p for interaction with obesity <0.001). The aHR (95% CIs) for developing HS plus high FIB-4 was 3.41 (1.33-8.74) for CES-D ⩾ 16 among obese individuals, and 1.22 (0.60-2.47) for CES-D ⩾ 16 among non-obese individuals (p for interaction = 0.201).
Conclusions: Depression was associated with an increased risk of incident HS and HS plus high probability of advanced fibrosis, especially among obese individuals.

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