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Tytuł:
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In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.
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Autorzy:
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Ten-Caten F; Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, University of São Paulo, São Paulo, Brazil.
Gonzalez-Dias P; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Castro Í; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Ogava RLT; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Giddaluru J; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Silva JCS; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Martins F; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Gonçalves ANA; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Scientific Platform Pasteur-University of São Paulo, São Paulo, Brazil.
Costa-Martins AG; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Scientific Platform Pasteur-University of São Paulo, São Paulo, Brazil.
Araujo JD; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Viegas AC; Division of Nephrology, Medicine Department, School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Cunha FQ; Center of Research in Inflammatory Diseases (CRID), University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
Farsky S; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Bozza FA; D'Or Institute for Research and Education, Brazil.
Levin AS; Department of Infectious Diseases, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Pannaraj PS; Division of Infectious Diseases, Children's Hospital Los Angeles and Department of Pediatrics, Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
de Silva TI; The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, UK.
Minoprio P; Scientific Platform Pasteur-University of São Paulo, São Paulo, Brazil.
Pinheiro da Silva F; Departamento de Emergências Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Andrade BB; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, 40296-710, Brazil. Electronic address: .
Nakaya HI; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Scientific Platform Pasteur-University of São Paulo, São Paulo, Brazil; Center of Research in Inflammatory Diseases (CRID), University of São Paulo, Ribeirao Preto, São Paulo, Brazil. Electronic address: .
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Źródło:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Apr; Vol. 105, pp. 579-587. Date of Electronic Publication: 2021 Mar 10.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Hamilton, ON : Elsevier
Original Publication: Hamilton, ON : Decker, c1996-
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MeSH Terms:
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SARS-CoV-2*
COVID-19/*blood
Inflammation/*etiology
Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; C-Reactive Protein/analysis ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Sex Characteristics ; Young Adult
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References:
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Contributed Indexing:
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Keywords: COVID-19; Coagulopathy; Infection; Neutrophils; Sex differences
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Substance Nomenclature:
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9007-41-4 (C-Reactive Protein)
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Entry Date(s):
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Date Created: 20210313 Date Completed: 20210513 Latest Revision: 20210518
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Update Code:
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20240104
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PubMed Central ID:
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PMC7944763
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DOI:
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10.1016/j.ijid.2021.03.016
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PMID:
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33713813
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Background: The progression and severity of COVID-19 vary significantly in the population. While the hallmarks of SARS-CoV-2 and severe COVID-19 within routine laboratory parameters are emerging, the impact of sex and age on these profiles is still unknown.
Methods: A multidimensional analysis was performed involving millions of records of laboratory parameters and diagnostic tests for 178 887 individuals from Brazil, of whom 33 266 tested positive for SARS-CoV-2. Analyzed data included those relating to complete blood cell count, electrolytes, metabolites, arterial blood gases, enzymes, hormones, cancer biomarkers, and others.
Findings: COVID-19 induced similar alterations in laboratory parameters in males and females. CRP and ferritin were increased, especially in older men with COVID-19, whereas abnormal liver function tests were common across several age groups, except for young women. Low peripheral blood basophils and eosinophils were more common in the elderly with COVID-19. Both male and female COVID-19 patients admitted to intensive care units displayed alterations in the coagulation system, and higher values for neutrophils, CRP, and lactate dehydrogenase.
Conclusions: Our study uncovered the laboratory profiles of a large cohort of COVID-19 patients, which formed the basis of discrepancies influenced by aging and biological sex. These profiles directly linked COVID-19 disease presentation to an intricate interplay between sex, age, and immune activation.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
