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Tytuł:
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Effect of carboxymethyl chitosan on the detoxification and biotransformation of paralytic shellfish toxins in oyster Ostrea rivularis.
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Autorzy:
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Yang X; College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Shandong, Qingdao, 266042, China; Shandong Provincial Key Laboratory of Biochemical Engineering, Shandong, Qingdao, 266042, China.
Hu X; College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Shandong, Qingdao, 266042, China.
Dong Z; College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Shandong, Qingdao, 266042, China.
Li M; College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Shandong, Qingdao, 266042, China.
Zheng Z; College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Shandong, Qingdao, 266042, China; Shandong Provincial Key Laboratory of Biochemical Engineering, Shandong, Qingdao, 266042, China.
Xie W; College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Shandong, Qingdao, 266042, China; Shandong Provincial Key Laboratory of Biochemical Engineering, Shandong, Qingdao, 266042, China. Electronic address: .
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Źródło:
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Toxicon : official journal of the International Society on Toxinology [Toxicon] 2021 Jun; Vol. 196, pp. 1-7. Date of Electronic Publication: 2021 Mar 12.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Oxford ; New York : Pergamon Press, c1962-
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MeSH Terms:
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Chitosan*
Dinoflagellida*/metabolism
Ostrea*/metabolism
Shellfish Poisoning*
Animals ; Biotransformation ; Humans ; Marine Toxins/metabolism ; Shellfish/analysis
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Contributed Indexing:
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Keywords: Biotransformation; Carboxymethyl chitosan; Detoxification; Paralytic shellfish toxins; Platymonas subcordiformis
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Substance Nomenclature:
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0 (Marine Toxins)
9012-76-4 (Chitosan)
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Entry Date(s):
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Date Created: 20210315 Date Completed: 20210512 Latest Revision: 20210512
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Update Code:
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20240104
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DOI:
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10.1016/j.toxicon.2021.03.006
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PMID:
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33716070
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Economic bivalve ingested toxic algae causes frequent human poisoning events. To explore new compounds that can accelerate the depuration of toxins in shellfish, we investigated the detoxification of the paralytic shellfish toxins (PSTs) and the biotransformation pathway of PSTs during detoxification by the application of three treatments to a toxic bloom, Alexandrium minutum (A. minutum). The detoxification effect of Platymonas subcordiformis (PS) mixed with carboxymethyl chitosan (CMC) group is significantly better than the starving group in each oyster tissues. The toxicity of viscera which occupied 78.95% of total toxicity reduced to 155 MU/100g after 13 days' depuration experiment. And adding CMC could significantly achieve rapid detoxification and effectively reduce the STX to 0.07 μmol/100 g in viscera. Meanwhile, PSTs underwent biotransformation during the depuration process, which mainly manifested as GTX1/4→GTX2/3→STX, GTX2→dcGTX2. This study explored a new strategy for toxin depuration in shellfish.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
