Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets.

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Abstrakt

Tytuł:: Potential interactions between an oral fosfomycin formulation and feed or drinking water: Impact on bioavailability in piglets.
Autorzy:: Decundo JM; Área Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.; Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN, UNCPBA-CICPBA-CONICET, Tandil, Argentina.
Diéguez SN; Área Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.; Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN, UNCPBA-CICPBA-CONICET, Tandil, Argentina.; Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC-PBA, Tandil, Argentina.
Amanto FA; Área Producción Porcina, Departamento de Producción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.
Martínez G; Área Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.; Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN, UNCPBA-CICPBA-CONICET, Tandil, Argentina.
Pérez Gaudio DS; Área Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.; Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN, UNCPBA-CICPBA-CONICET, Tandil, Argentina.
Fernández Paggi MB; Área Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.; Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN, UNCPBA-CICPBA-CONICET, Tandil, Argentina.; Área Producción Porcina, Departamento de Producción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.
Romanelli A; Área Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.; Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN, UNCPBA-CICPBA-CONICET, Tandil, Argentina.; Área Fisiología de la Nutrición, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.
Soraci AL; Área Toxicología, Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.; Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil (CIVETAN, UNCPBA-CICPBA-CONICET, Tandil, Argentina.
Źródło:: Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2021 Sep; Vol. 44 (5), pp. 783-792. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Oxford, Blackwell Scientific Publications.
MeSH Terms:: Drinking Water*
Fosfomycin*
Administration, Oral ; Animals ; Biological Availability ; Solubility ; Swine
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Contributed Indexing:: Keywords: bioavailability; drinking water; feed; oral antibiotics; piglets
Substance Nomenclature:: 0 (Drinking Water)
2N81MY12TE (Fosfomycin)
Entry Date(s):: Date Created: 20210315 Date Completed: 20211124 Latest Revision: 20211124
Update Code:: 20240104
DOI:: 10.1111/jvp.12966
PMID:: 33720436
: Czasopismo naukowe

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Feed and drinking water are the most frequently used vehicles for administration of antibiotics in intensive pig production. Interactions of drugs with feed and water components may affect dissolution and bioavailability. Therefore, antibiotic formulations should be tested in order to assure their suitability for oral use. In this study, an oral fosfomycin (FOS) formulation was evaluated considering dissolution in water (soft and hard), release kinetics from feed in simulated gastrointestinal fluids and bioavailability after oral administration blended into feed or dissolved in water (soft and hard), to fed and fasted piglets. FOS reached immediate dissolution in soft and hard water. The presence of feed significantly decreased antibiotic dissolution in simulated intestinal medium. Bioavailability was lower when feed was used as a vehicle for FOS administration than when the drug was dissolved in water (soft or hard). The fed or fasted condition of piglets did not affect bioavailability. Probably, FOS interactions with feed components alter its dissolution in the gastrointestinal tract, and only a fraction of the dose would be available for absorption. This information must be considered to support decisions on eligibility of antibiotic pharmaceutical formulations and the vehicle for their administration in order to pursue a responsible use of antibiotics.
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