Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected children: A retrospective study.

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Tytuł:: Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected children: A retrospective study.
Autorzy:: Li Y; Department of Respiratory Medicine, Wuhan Children' Hospital.
Wang H; Department of Gastroenterology, Zhongnan Hospital of Wuhan University.; Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, China.
Wang F; Department of Gastroenterology, Zhongnan Hospital of Wuhan University.; Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, China.
Lu X; Department of Respiratory Medicine, Wuhan Children' Hospital.
Du H; Department of Respiratory Medicine, Wuhan Children' Hospital.
Xu J; Department of Respiratory Medicine, Wuhan Children' Hospital.
Han F; Department of Respiratory Medicine, Wuhan Children' Hospital.
Zhang L; Department of Respiratory Medicine, Wuhan Children' Hospital.
Zhang M; Department of Respiratory Medicine, Wuhan Children' Hospital.
Źródło:: Medicine [Medicine (Baltimore)] 2021 Mar 19; Vol. 100 (11), pp. e24315.
Typ publikacji:: Journal Article; Observational Study
Język:: English
Imprint Name(s):: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
MeSH Terms:: COVID-19/*epidemiology
Coinfection/*epidemiology
Adenoviridae Infections/epidemiology ; Child ; Child, Preschool ; China/epidemiology ; Coinfection/microbiology ; Coinfection/virology ; Female ; Humans ; Influenza, Human/epidemiology ; Leukocyte Count ; Lymphocyte Count ; Male ; Moraxellaceae Infections/epidemiology ; Mycoplasma pneumoniae ; Pneumococcal Infections/epidemiology ; Pneumonia, Mycoplasma/epidemiology ; Respiratory Syncytial Virus Infections/epidemiology ; Retrospective Studies ; SARS-CoV-2
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Entry Date(s):: Date Created: 20210317 Date Completed: 20210325 Latest Revision: 20230103
Update Code:: 20240105
PubMed Central ID:: PMC7982148
DOI:: 10.1097/MD.0000000000024315
PMID:: 33725930
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Abstract: Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, considerable attention has been paid on its epidemiology and clinical characteristics in children patients. However, it is also crucial for clinicians to summarize and investigate the co-infection of SARS-CoV-2 in children.We retrospectively reviewed the clinical manifestations, laboratory findings, and imaging characteristics of COVID-19 patients in co-infection group (CI, n = 27) and single infection group (SI, n = 54). Samples were tested for multiple pathogens.A high incidence (27/81, 33%) of co-infection in children with COVID-19 was revealed. The most frequent co-infected pathogen was mycoplasma pneumoniae (MP, 20/81, 25%), followed by virus (6/81, 7%), and bacteria (4/81, 5%). No significant difference in clinical characteristics, laboratory examinations, or hospital stay was observed between the patients with co-infections and those with monomicrobial, only lower in white blood cell counts (CI: 5.54 ± 0.36 vs SI: 7.38 ± 0.37, P = .002), neutrophil counts (CI: 2.20 ± 0.20 vs SI: 2.92 ± 0.23, P = .024) and lymphocyte counts (CI: 2.72 ± 0.024 vs SI: 3.87 ± 0.28, P = .006). Compared with the patients with monomicrobial, chest imaging of those with co-infections showed consolidation in more cases (CI: 29.6% vs SI: 11.1%, P = .038) and duration of positive in nucleic acid was shorter (CI: 6.69 ± 0.82 vs SI: 9.69 ± 0.74, P = .015).Co-infection was relatively common in children with COVID-19, almost 1/3 had co-infection, most commonly caused by MP. Co-infection did not cause a significant exacerbation in clinical manifestations.
Competing Interests: The authors have no conflicts of interests to disclose.
(Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)

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