The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans.

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Tytuł:: The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans.
Autorzy:: Esh CJ; Aspetar-Qatar Orthopaedic and Sports Medicine Hospital, Athlete Health and Performance Research Centre, Aspire Zone, Doha, Qatar.; School of Sport, Exercise and Health Sciences, Loughborough University, Epinal Way, Loughborough, LE11 3TU, UK.
Chrismas BCR; Department of Physical Education, College of Education, Qatar University, Doha, Qatar.
Mauger AR; Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Chatham, UK.
Cherif A; Aspetar-Qatar Orthopaedic and Sports Medicine Hospital, Athlete Health and Performance Research Centre, Aspire Zone, Doha, Qatar.
Molphy J; Aspetar-Qatar Orthopaedic and Sports Medicine Hospital, Athlete Health and Performance Research Centre, Aspire Zone, Doha, Qatar.
Taylor L; Aspetar-Qatar Orthopaedic and Sports Medicine Hospital, Athlete Health and Performance Research Centre, Aspire Zone, Doha, Qatar. .; School of Sport, Exercise and Health Sciences, Loughborough University, Epinal Way, Loughborough, LE11 3TU, UK. .; Sport & Exercise Discipline Group, Faculty of Health, University of Technology Sydney (UTS), Sydney, Australia. .; Human Performance Research Centre, University of Technology Sydney (UTS), Sydney, Australia. .
Źródło:: Scientific reports [Sci Rep] 2021 Mar 22; Vol. 11 (1), pp. 6531. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Body Temperature Regulation/*genetics
Cyclooxygenase 2/*genetics
Dinoprostone/*genetics
Skin Temperature/*genetics
Adult ; Biological Availability ; Body Temperature ; Cold Temperature ; Hot Temperature ; Humans ; Male
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Substance Nomenclature:: EC 1.14.99.1 (Cyclooxygenase 2)
K7Q1JQR04M (Dinoprostone)
Entry Date(s):: Date Created: 20210323 Date Completed: 20211013 Latest Revision: 20211013
Update Code:: 20240105
PubMed Central ID:: PMC7985197
DOI:: 10.1038/s41598-021-84563-5
PMID:: 33753764
: Czasopismo naukowe

Pełny tekst

Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4-1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [- 0.5 (- 0.8 to - 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (- 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.

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