-
Tytuł:
-
Bronchiectasis is associated with delayed diagnosis and adverse outcomes in the New Zealand Common Variable Immunodeficiency Disorders cohort study.
-
Autorzy:
-
Ameratunga R; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.; Department of Virology and Immunology, Auckland City Hospital, Auckland, New Zealand.; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
Jordan A; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.
Cavadino A; School of Population Health, University of Auckland, Auckland, New Zealand.
Ameratunga S; School of Population Health, University of Auckland, Auckland, New Zealand.; Population Health Directorate, Counties Manukau Health, Auckland, New Zealand.
Hills T; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.
Steele R; Department of Virology and Immunology, Auckland City Hospital, Auckland, New Zealand.
Hurst M; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.
McGettigan B; Department of Clinical Immunology, Fiona Stanley Hospital, Perth, WA, Australia.
Chua I; Department of Clinical Immunology, Christchurch Hospital, Christchurch, New Zealand.
Brewerton M; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.
Kennedy N; Department of Respiratory Medicine, Wellington Hospital, Wellington, New Zealand.
Koopmans W; Department of Virology and Immunology, Auckland City Hospital, Auckland, New Zealand.
Ahn Y; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.; Department of Virology and Immunology, Auckland City Hospital, Auckland, New Zealand.
Barker R; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.
Allan C; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.
Storey P; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.
Slade C; Walter and Eliza Hall Institute, Melbourne, VIC, Australia.
Baker A; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.
Huang L; Department of Virology and Immunology, Auckland City Hospital, Auckland, New Zealand.
Woon ST; Department of Clinical Immunology, Auckland City Hospital, Auckland, New Zealand.; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.
-
Źródło:
-
Clinical and experimental immunology [Clin Exp Immunol] 2021 Jun; Vol. 204 (3), pp. 352-360. Date of Electronic Publication: 2021 Apr 12.
-
Typ publikacji:
-
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Publication: 2022- : Oxford : Oxford University Press
Original Publication: Oxford : Blackwell Scientific Publications
-
MeSH Terms:
-
Bronchiectasis/*immunology
Common Variable Immunodeficiency/*immunology
Cohort Studies ; Delayed Diagnosis ; Female ; Humans ; Immunoglobulins, Intravenous/immunology ; Longitudinal Studies ; Male ; Middle Aged ; New Zealand ; Prevalence
-
References:
-
Neurology. 2004 Mar 9;62(5):833-4. (PMID: 15007150)
N Z Med J. 2016 Jun 10;129(1436):75-90. (PMID: 27355232)
J Clin Immunol. 2015 Aug;35(6):589-94. (PMID: 26318181)
Front Immunol. 2019 Jan 15;9:3146. (PMID: 30697212)
Allergy Asthma Clin Immunol. 2013 Sep 17;9(1):36. (PMID: 24341706)
Front Immunol. 2017 Sep 28;8:1190. (PMID: 29033928)
Immunol Allergy Clin North Am. 2015 Nov;35(4):637-58. (PMID: 26454311)
PLoS One. 2015 Oct 13;10(10):e0140473. (PMID: 26461272)
Clin Transl Immunology. 2017 Oct 20;6(10):e159. (PMID: 29114388)
Front Immunol. 2019 Nov 22;10:2678. (PMID: 31824486)
Front Immunol. 2019 Jul 17;10:1541. (PMID: 31379811)
Orphanet J Rare Dis. 2018 Nov 12;13(1):201. (PMID: 30419968)
Pediatr Pulmonol. 2020 Feb;55(2):292-299. (PMID: 31833673)
J Allergy Clin Immunol. 2014 Jul;134(1):116-26. (PMID: 24582312)
Am J Hum Genet. 2015 Sep 3;97(3):389-403. (PMID: 26279205)
Front Immunol. 2016 Jun 13;7:220. (PMID: 27379089)
Blood. 2008 Jul 15;112(2):277-86. (PMID: 18319398)
Pathology. 2000 Nov;32(4):280-2. (PMID: 11186425)
Allergy Asthma Clin Immunol. 2019 Dec 2;15:78. (PMID: 31827542)
Clin Infect Dis. 2008 May 15;46(10):1547-54. (PMID: 18419489)
Front Immunol. 2018 Jan 26;8:1965. (PMID: 29434582)
Clin Exp Immunol. 2013 Nov;174(2):203-11. (PMID: 23859429)
J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1763-1770. (PMID: 30776527)
Blood. 2020 Feb 27;135(9):656-667. (PMID: 31942606)
Front Immunol. 2019 Jul 24;10:1754. (PMID: 31396239)
Front Immunol. 2020 Mar 31;11:522. (PMID: 32296433)
Front Immunol. 2018 Sep 28;9:2130. (PMID: 30323807)
Front Immunol. 2018 May 14;9:694. (PMID: 29867917)
Immunol Allergy Clin North Am. 2020 Aug;40(3):403-420. (PMID: 32654689)
Clin Exp Immunol. 2019 Nov;198(2):224-232. (PMID: 31260083)
Scand J Immunol. 2017 Jun;85(6):450-461. (PMID: 28370285)
Clin Rev Allergy Immunol. 2020 Aug;59(1):109-121. (PMID: 31720921)
J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):38-59. (PMID: 26563668)
J Allergy Clin Immunol. 2020 Oct;146(4):901-911. (PMID: 32278790)
-
Contributed Indexing:
-
Keywords: CVID; HGUS; IVIG; SCIG; bronchiectasis; hypogammaglobulinaemia
-
Substance Nomenclature:
-
0 (Immunoglobulins, Intravenous)
-
Entry Date(s):
-
Date Created: 20210323 Date Completed: 20211203 Latest Revision: 20220716
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC8119856
-
DOI:
-
10.1111/cei.13595
-
PMID:
-
33755987
-
Common variable immunodeficiency disorders (CVID) are multi-system disorders where target organ damage is mediated by infective, autoimmune and inflammatory processes. Bronchiectasis is probably the most common disabling complication of CVID. The risk factors for bronchiectasis in CVID patients are incompletely understood. The New Zealand CVID study (NZCS) is a nationwide longitudinal observational study of adults, which commenced in 2006. In this analysis, the prevalence and risk factors for bronchiectasis were examined in the NZCS. After informed consent, clinical and demographic data were obtained with an interviewer-assisted questionnaire. Linked electronic clinical records and laboratory results were also reviewed. Statistical methods were applied to determine if variables such as early-onset disease, delay in diagnosis and increased numbers of infections were associated with greater risk of bronchiectasis. One hundred and seven adult patients with a diagnosis of CVID are currently enrolled in the NZCS, comprising approximately 70% of patients known to have CVID in New Zealand. Fifty patients (46·7%) had radiologically proven bronchiectasis. This study has shown that patients with compared to those without bronchiectasis have an increased mortality at a younger age. CVID patients with bronchiectasis had a greater number of severe infections consequent to early-onset disease and delayed diagnosis. Indigenous Māori have a high prevalence of CVID and a much greater burden of bronchiectasis compared to New Zealand Europeans. Diagnostic latency has not improved during the study period. Exposure to large numbers of infections because of early-onset disease and delayed diagnosis was associated with an increased risk of bronchiectasis. Earlier diagnosis and treatment of CVID may reduce the risk of bronchiectasis and premature death in some patients.
(© 2021 British Society for Immunology.)
