Low blood caspase-8 levels in survivor patients of traumatic brain injury.

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Abstrakt

Tytuł:: Low blood caspase-8 levels in survivor patients of traumatic brain injury.
Autorzy:: Lorente L; Intensive Care Unit, Hospital Universitario de Canarias, Ofra s/n La Laguna, 38320, Santa Cruz de Tenerife, Spain. .
Martín MM; Intensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, Crta del Rosario s/n, 38010, Santa Cruz de Tenerife, Spain.
Pérez-Cejas A; Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, 38320, Santa Cruz de Tenerife, Spain.
González-Rivero AF; Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Ramos-Gómez L; Intensive Care Unit, Hospital General de La Palma, Buenavista de Arriba s/n, 38713, Breña Alta, La Palma, Spain.
Solé-Violán J; Intensive Care Unit, Hospital Universitario Dr. Negrín, CIBERES Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
Cáceres JJ; Intensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain.
Ferrer-Moure C; Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Jiménez A; Research Unit, Hospital Universitario de Canarias, Ofra s/n La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Źródło:: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2021 Dec; Vol. 42 (12), pp. 5065-5070. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji:: Journal Article; Observational Study
Język:: English
Imprint Name(s):: Original Publication: Milano, Italy : Springer-Verlag Italia, c2000-
MeSH Terms:: Brain Injuries*
Brain Injuries, Traumatic*/complications
Caspase 8 ; Glasgow Coma Scale ; Humans ; Survivors
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Grant Information:: PI-18-00500 Instituto de Salud Carlos III (ES)
Contributed Indexing:: Keywords: Brain; Caspase-8; Injury; Mortality; Patients; Trauma
Substance Nomenclature:: EC 3.4.22.- (Caspase 8)
Entry Date(s):: Date Created: 20210324 Date Completed: 20211207 Latest Revision: 20211214
Update Code:: 20240105
DOI:: 10.1007/s10072-021-05205-2
PMID:: 33759054
: Czasopismo naukowe

Pełny tekst

Objective: High concentrations of caspase-8 (main initiator caspase of the extrinsic pathway of apoptosis) have been found in brain tissue of patients with traumatic brain injury (TBI) and in the blood of patients with different diseases. However, blood caspase-8 concentrations in TBI patients have not been reported. Therefore, our aim was to analyze whether blood caspase-8 concentrations are associated with mortality in TBI patients.
Method: Patients with isolated and severe TBI were included. TBI was considered isolated if it showed an Injury Severity Score (ISS) <10 points on non-cranial aspects. TBI was considered severe if it showed a Glasgow Coma Scale (GCS) <9 points. This prospective observational study was conducted in 5 Intensive Care Units. Serum caspase-8 concentrations were measured on day 1 of TBI.
Results: Surviving patients (n=59) had lower age (p=0.004), higher GCS (p=0.001), lower APACHE-II score (p<0.001), lower high-risk-of-death computed tomography (CT) findings (p=0.02), lower intracranial pressure (ICP) (p=0.01), and lower serum caspase-8 concentrations (p<0.001) than non-surviving patients (n=24). An association was found between serum caspase-8 levels and mortality after controlling for CT findings, GCS, and age (OR=1.037; 95% CI=1.013-1.062; p=0.002), and after controlling for CT findings, APACHE-II, and ICP (OR=1.042; 95% CI=1.013-1.071; p=0.004) in multiple logistic regression.
Conclusions: To our knowledge, this is the first series describing blood caspase-8 concentrations in patients with TBI. The association of high blood caspase-8 concentrations with mortality was the main new finding of the study. However, further investigations are needed to validate the preliminary results of our study.
(© 2021. Fondazione Società Italiana di Neurologia.)

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