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Tytuł pozycji:

Effect of restoration of euthyroidism on visfatin concentrations and body composition in women.

Tytuł :
Effect of restoration of euthyroidism on visfatin concentrations and body composition in women.
Autorzy :
Sawicka-Gutaj N; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Zybek-Kocik A; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Kloska M; Lehigh Valley Health Network, Department of Medicine, Lehigh Valley Hospital - Cedar Crest, Allentown, USA.
Ziółkowska P; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Czarnywojtek A; Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland.
Sowiński J; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Mańkowska-Wierzbicka D; Department of Gastroenterology, Internal Medicine, Metabolic Diseases and Dietetics, Poznan University of Medical Sciences, Poznan, Poland.
Ruchała M; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Pokaż więcej
Źródło :
Endocrine connections [Endocr Connect] 2021 Apr 26; Vol. 10 (4), pp. 462-470. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Bristol : BioScientifica
Contributed Indexing :
Keywords: Graves’ disease; Hashimoto’s disease; fat tissue; nicotinamide phosphoribosyltransferase; pre-B-cell colony enhancing factor; visfatin
Entry Date(s) :
Date Created: 20210325 Latest Revision: 20210428
Update Code :
20210428
DOI :
10.1530/EC-21-0059
PMID :
33764900
Czasopismo naukowe
Dysregulation of thyroid function has known impact on body metabolism, however, data regarding metabolic outcome after restoration of thyroid function is limited. Therefore, the aim of the study was to investigate the effect of restoration of euthyroidism on serum visfatin, and its associations with insulin resistance and body composition. This is an observational study with consecutive enrollment. Forty-nine hyperthyroid (median age of 34 years) and 44 hypothyroid women (median age of 46 years) completed the study. Laboratory parameters and body composition analysis were assessed before and after the therapy. In the hyperthyroid group, visfatin concentrations increased (P < 0.0001), while glucose concentrations decreased (P < 0.0001). Total body mass and fat mass in the trunk and limbs significantly increased during the treatment. In the hypothyroid group, significant weight loss resulted from decrease of fat and muscle masses in trunk and limbs. Visfatin serum concentrations positively correlated with total fat mass (r = 0.19, P = 0.01) and insulin concentrations (r = 0.17, P = 0.018). In conclusion, restoration of thyroid function is not associated with beneficial changes in body composition, especially among hyperthyroid females.

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