Hyaluronic acid/polyethyleneimine nanoparticles loaded with copper ion and disulfiram for esophageal cancer.

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Tytuł:: Hyaluronic acid/polyethyleneimine nanoparticles loaded with copper ion and disulfiram for esophageal cancer.
Autorzy:: Xu R; School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, PR China.
Zhang K; School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, PR China.
Liang J; School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, PR China.
Gao F; School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, PR China.
Li J; School of Materials Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, PR China. Electronic address: .
Guan F; School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, PR China. Electronic address: .
Źródło:: Carbohydrate polymers [Carbohydr Polym] 2021 Jun 01; Vol. 261, pp. 117846. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <1992-> : Barking : Elsevier Applied Science Publishers
Original Publication: London [Eng.] : Applied Science Publishers, c1981-
MeSH Terms:: Carcinoma, Squamous Cell/*drug therapy
Copper/*administration & dosage
Disulfiram/*administration & dosage
Esophageal Neoplasms/*drug therapy
Hyaluronic Acid/*chemistry
Nanoparticles/*chemistry
Polyethyleneimine/*chemistry
Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Apoptosis/drug effects ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cells, Cultured ; Copper/pharmacokinetics ; Disulfiram/pharmacokinetics ; Drug Carriers/chemical synthesis ; Drug Carriers/chemistry ; Drug Carriers/therapeutic use ; Drug Delivery Systems ; Drug Liberation ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Heavy Ions ; Humans ; Hyaluronic Acid/chemical synthesis ; Hyaluronic Acid/therapeutic use ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nanoparticles/therapeutic use ; Polyethyleneimine/chemical synthesis ; Polyethyleneimine/therapeutic use ; Xenograft Model Antitumor Assays
Contributed Indexing:: Keywords: Disulfiram/Cu(2+); Drug loaded nanoparticles; Effectiveness and targeting; Esophageal cancer; Hyaluronic acid
Substance Nomenclature:: 0 (Antineoplastic Agents)
0 (Drug Carriers)
789U1901C5 (Copper)
9002-98-6 (Polyethyleneimine)
9004-61-9 (Hyaluronic Acid)
TR3MLJ1UAI (Disulfiram)
Entry Date(s):: Date Created: 20210326 Date Completed: 20210503 Latest Revision: 20210503
Update Code:: 20240105
DOI:: 10.1016/j.carbpol.2021.117846
PMID:: 33766342
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In the clinical treatment of cancer, improving the effectiveness and targeting of drugs has always been a bottleneck problem that needs to be solved. In this contribution, inspired by the targeted inhibition on cancer from combination application of disulfiram and divalent copper ion (Cu 2+ ), we optimized the concentration of disulfiram and Cu 2+ ion for inhibiting esophageal cancer cells, and loaded them in hyaluronic acid (HA)/polyethyleneimine (PEI) nanoparticles with specific scales, in order to improve the effectiveness and targeting of drugs. The in vitro cell experiments demonstrated that more drug loaded HA/PEI nanoparticles accumulated to the esophageal squamous cell carcinoma (Eca109) and promoted higher apoptosis ratio of Eca109. Both in vitro and in vivo biological assessment verified that the disulfiram/Cu 2+ loaded HA/PEI nanoparticles promoted the apoptosis of cancer cells and inhibited the tumor proliferation, but had no toxicity on other normal organs.
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