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Tytuł:
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A double-network polysaccharide-based composite hydrogel for skin wound healing.
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Autorzy:
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He Y; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Li Y; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Sun Y; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Zhao S; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Feng M; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Xu G; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Zhu H; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Ji P; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China; NJTech-BARTY Joint Research Center for Innovative Medical Technology, Nanjing, 210000, China.
Mao H; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China; Research Institute for Biomaterials, Tech Institute for Advanced Materials, Nanjing Tech University, Nanjing, 210000, China; NJTech-BARTY Joint Research Center for Innovative Medical Technology, Nanjing, 210000, China; Jiangsu Collaborative Innovation Center for Advanced Inorganic Functional Composites, Nanjing Tech University, Nanjing, 211816, China. Electronic address: .
He Y; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China; Research Institute for Biomaterials, Tech Institute for Advanced Materials, Nanjing Tech University, Nanjing, 210000, China; Suqian Advanced Materials Industry Technology Innovation Center of Nanjing Tech University, Nanjing, 211816, China.
Gu Z; College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, China; Research Institute for Biomaterials, Tech Institute for Advanced Materials, Nanjing Tech University, Nanjing, 210000, China; NJTech-BARTY Joint Research Center for Innovative Medical Technology, Nanjing, 210000, China; Suqian Advanced Materials Industry Technology Innovation Center of Nanjing Tech University, Nanjing, 211816, China. Electronic address: .
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Źródło:
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Carbohydrate polymers [Carbohydr Polym] 2021 Jun 01; Vol. 261, pp. 117870. Date of Electronic Publication: 2021 Feb 25.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <1992-> : Barking : Elsevier Applied Science Publishers
Original Publication: London [Eng.] : Applied Science Publishers, c1981-
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MeSH Terms:
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Bandages, Hydrocolloid*
Hydrogels*/chemical synthesis
Hydrogels*/chemistry
Hydrogels*/therapeutic use
Polysaccharides/*chemistry
Wound Healing/*drug effects
Alginates/chemical synthesis ; Alginates/chemistry ; Alginates/therapeutic use ; Animals ; Cells, Cultured ; Chitosan/analogs & derivatives ; Chitosan/chemical synthesis ; Chitosan/chemistry ; Chitosan/therapeutic use ; Collagen/chemical synthesis ; Collagen/chemistry ; Collagen/pharmacokinetics ; Collagen/therapeutic use ; Humans ; Materials Testing ; Mice ; Peptide Fragments/chemical synthesis ; Peptide Fragments/chemistry ; Peptide Fragments/pharmacokinetics ; Peptide Fragments/therapeutic use ; Polysaccharides/therapeutic use ; Skin/drug effects ; Skin/injuries ; Skin/pathology
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Contributed Indexing:
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Keywords: Carboxymethyl chitosan; Collagen peptide; Double-network hydrogel; Oxidized methacrylate sodium alginate; Wound dressing
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Substance Nomenclature:
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0 (Alginates)
0 (Hydrogels)
0 (Peptide Fragments)
0 (Polysaccharides)
0 (carboxymethyl-chitosan)
9007-34-5 (Collagen)
9012-76-4 (Chitosan)
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Entry Date(s):
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Date Created: 20210326 Date Completed: 20210503 Latest Revision: 20210503
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Update Code:
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20240105
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DOI:
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10.1016/j.carbpol.2021.117870
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PMID:
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33766357
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Effective wound dressings are of great significance in preventing infections and promoting wound healing. However, most existing hydrogel dressings have an inadequacy in either mechanical performance, biological activities, or versatilities. Here we presented a double-network cross-linked polysaccharide-based hydrogel composed of collagen peptide-functionalized carboxymethyl chitosan (CS) and oxidized methacrylate sodium alginate (SA). The hydrogel possessed interconnected porous morphologies, suitable swelling ratios, excellent mechanical properties, and favorable biocompatibility. Meanwhile, the in vivo studies using a mouse full-thickness skin defect model showed that the double-network CS/SA hydrogel significantly accelerated wound healing by regulating the inflammatory process, promoting collagen deposition, and improving vascularization. Therefore, the functionalized double-network hydrogel should be a potential candidate as wound dressings.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
