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Tytuł:
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Recent advances in the design of microfluidic technologies for the manufacture of drug releasing particles.
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Autorzy:
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Forigua A; Department of Chemistry, University of Victoria, Victoria, BC V8W 2Y2, Canada.
Kirsch RL; Department of Chemistry, University of Victoria, Victoria, BC V8W 2Y2, Canada; Department of Mechanical Engineering, University of Victoria, Victoria, BC V8W 2Y2, Canada.
Willerth SM; Department of Mechanical Engineering, University of Victoria, Victoria, BC V8W 2Y2, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC V8W 2Y2, Canada. Electronic address: .
Elvira KS; Department of Chemistry, University of Victoria, Victoria, BC V8W 2Y2, Canada. Electronic address: .
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Źródło:
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Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 May 10; Vol. 333, pp. 258-268. Date of Electronic Publication: 2021 Mar 22.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier Science Publishers, 1984-
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MeSH Terms:
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Microfluidics*
Pharmaceutical Preparations*
Biocompatible Materials ; Drug Delivery Systems ; Particle Size
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Contributed Indexing:
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Keywords: Droplets; Drug release; Microfluidics; Microparticles; Nanoparticles
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Substance Nomenclature:
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0 (Biocompatible Materials)
0 (Pharmaceutical Preparations)
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Entry Date(s):
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Date Created: 20210326 Date Completed: 20210707 Latest Revision: 20210707
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Update Code:
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20240105
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DOI:
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10.1016/j.jconrel.2021.03.019
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PMID:
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33766691
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Drug releasing particles are valued for their ability to deliver therapeutics to targeted locations and for their controllable release patterns. The development of microfluidic technologies, which are designed specifically to manipulate small amounts of fluids, to manufacture particles for drug delivery applications reflects a recent trend due to the advantages they confer in terms of control over particle size and material composition. This review takes a comprehensive look at the different types of microfluidic devices used to fabricate such particles from different types of biomaterials, and at how the on-chip features enable the production of particles with different types of properties. The review concludes by suggesting avenues for future work that will enable these technologies to fulfill their potential and be used in industrial settings for the manufacture of drug releasing particles with unique capabilities.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
