Eurotium cristatum Fermented Loose Dark Tea Ameliorates Cigarette Smoke-Induced Lung Injury by MAPK Pathway and Enhances Hepatic Metabolic Detoxification by PXR / AhR Pathway in Mice.

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Abstrakt

Tytuł:: Eurotium cristatum Fermented Loose Dark Tea Ameliorates Cigarette Smoke-Induced Lung Injury by MAPK Pathway and Enhances Hepatic Metabolic Detoxification by PXR / AhR Pathway in Mice.
Autorzy:: Huang XX; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Xu S; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Yu LJ; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Zhou YF; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Zhou Y; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.
Liu ZH; Key Laboratory of Tea Science of Ministry of Education, National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, College of Horticulture, Hunan Agricultural University, Changsha 410128, China.; Hunan Provincial Key Laboratory for Germplasm Innovation and Utilization of Crop, Hunan Agricultural University, Changsha 410128, China.
Źródło:: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Mar 10; Vol. 2021, pp. 6635080. Date of Electronic Publication: 2021 Mar 10 (Print Publication: 2021).
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
MeSH Terms:: Metabolic Detoxication, Phase I*
Aspergillus/*classification
Cigarette Smoking/*metabolism
Lung/*metabolism
Lung Injury/*drug therapy
MAP Kinase Signaling System/*drug effects
Plant Extracts/*pharmacology
Pregnane X Receptor/*metabolism
Receptors, Aryl Hydrocarbon/*metabolism
Signal Transduction/*drug effects
Animals ; Cigarette Smoking/pathology ; Female ; Lung/pathology ; Lung Injury/metabolism ; Mice ; Plant Extracts/chemistry
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Substance Nomenclature:: 0 (Nr1i2 protein, mouse)
0 (Plant Extracts)
0 (Pregnane X Receptor)
0 (Receptors, Aryl Hydrocarbon)
SCR Organism:: Aspergillus cristatus
Entry Date(s):: Date Created: 20210329 Date Completed: 20210520 Latest Revision: 20210520
Update Code:: 20240105
PubMed Central ID:: PMC7972846
DOI:: 10.1155/2021/6635080
PMID:: 33777316
: Czasopismo naukowe

Cigarette smoke- (CS-) induced oxidative stress and inflammation in the lung are serious health problems. Primary and reprocessed tea products contain multiple antioxidants that have been reported to protect the lung against CS-induced injury. However, the beneficial effects of Eurotium cristatum fermented loose dark tea (ECT) and Eurotium cristatum particle metabolites (ECP) on CS-induced lung injury and its potential hepatic metabolic detoxification are still unclear. Therefore, sixty mice were randomly divided into six equal groups. CS-exposed mice were prevented or treated with ECP or ECT infusions for 12 or 8 weeks to determine the antioxidative stress, anti-inflammatory and potential metabolic detoxification of ECT and ECP. Thirty-six mice were randomly divided into six equal groups to observe the effects on hepatic metabolic detoxification by replacing daily drinking water with ECT. Results showed that CS significantly decreased the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) and upregulated the expressions of malondialdehyde (MDA), tumor necrosis factor alpha (TNF- α ), interleukin-6 (IL-6), IL-8, and IL-1 β in serum. These adverse effects were modulated by ECP and ECT. In addition, ECT upregulated the mRNA expression of pregnane X receptor ( PXR ) and cytochrome P450 ( CYP450 ) in the liver on daily free drinking ECT mice group. Western blot analysis further revealed that in CS-exposed mice, ECP and ECT significantly decreased the phosphorylation of mitogen-activated protein kinase (MAPK) in the lung but upregulated the protein expressions of PXR and aryl hydrocarbon receptor ( AhR ) in the liver. Overall, our findings demonstrated that ECT and ECP protected against lung injury induced by CS via MAPK pathway and enhanced hepatic metabolic detoxification via PXR and AhR pathways. Therefore, daily intake of ECT and ECP can potentially protect against CS-induced oxidative and inflammatory injuries.
Competing Interests: The authors declare no conflict of interest.
(Copyright © 2021 Xiang-Xiang Huang et al.)

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