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Tytuł pozycji:

Abnormal phase discontinuity of alpha- and theta-frequency oscillations in schizophrenia.

Tytuł:
Abnormal phase discontinuity of alpha- and theta-frequency oscillations in schizophrenia.
Autorzy:
Koshiyama D; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Miyakoshi M; Swartz Center for Neural Computation, University of California San Diego, La Jolla, CA, USA. Electronic address: .
Tanaka-Koshiyama K; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Joshi YB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA.
Sprock J; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA.
Braff DL; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA.
Light GA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA.
Źródło:
Schizophrenia research [Schizophr Res] 2021 May; Vol. 231, pp. 73-81. Date of Electronic Publication: 2021 Mar 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: Amsterdam : Elsevier Science Publisher B. V., c1988-
MeSH Terms:
Schizophrenia*
Brain ; Electroencephalography ; Humans ; Memory ; Temporal Lobe
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Grant Information:
R01 MH042228 United States MH NIMH NIH HHS; R01 MH079777 United States MH NIMH NIH HHS; R37 MH042228 United States MH NIMH NIH HHS
Contributed Indexing:
Keywords: Alpha oscillation; Phase discontinuity; Resting-state electroencephalography (EEG); Schizophrenia; Source level analysis; Theta oscillation
Entry Date(s):
Date Created: 20210329 Date Completed: 20210705 Latest Revision: 20220503
Update Code:
20240105
PubMed Central ID:
PMC8222093
DOI:
10.1016/j.schres.2021.03.007
PMID:
33780847
Czasopismo naukowe
Background: Schizophrenia patients have abnormal electroencephalographic (EEG) power over multiple frequency bands, even at rest, though the primary neural generators and spatiotemporal dynamics of these abnormalities are largely unknown. Disturbances in the precise synchronization of oscillations within and across cortical sources may underlie abnormal resting-state EEG activity in schizophrenia patients.
Methods: A novel assessment method was applied to identify the independent contributing sources of resting-state EEG and assess the phase discontinuity in schizophrenia patients (N = 148) and healthy subjects (N = 143).
Results: A network of 11 primary contributing sources of scalp EEG was identified in both groups. Schizophrenia patients showed abnormal elevations of EEG power in the temporal region in the theta, beta, and gamma-bands, as well as the posterior cingulate gyrus in the delta, theta, alpha, and beta-bands. The higher theta-band power in the middle temporal gyrus was significantly correlated with verbal memory impairment in patients. The peak frequency of alpha was lower in patients in the cingulate and temporal regions. Furthermore, patients showed a higher rate of alpha phase discontinuity in the temporal region as well as a lower rate of theta phase discontinuity in the temporal and posterior cingulate regions.
Conclusions: Abnormal rates of phase discontinuity of alpha- and theta-band, abnormal elevations of EEG power in multiple bands, and a lower peak frequency of alpha were identified in schizophrenia patients at rest. Clarification of the mechanistic substrates of abnormal phase discontinuity may clarify core pathophysiologic abnormalities of schizophrenia and contribute to the development of novel biomarkers for therapeutic interventions.
Competing Interests: Declaration of competing interest G.A. Light reported consulting for Astellas Pharma, Inc., Heptares Therapeutics, NeuroSig, Neurocrine, and Novartis.
(Copyright © 2021 Elsevier B.V. All rights reserved.)

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