18F-FDG and 68Ga-FAPI PET/CT in the Evaluation of Ground-Glass Opacity Nodule.

Szczegóły
Abstrakt

Tytuł:: 18F-FDG and 68Ga-FAPI PET/CT in the Evaluation of Ground-Glass Opacity Nodule.
Autorzy:: Chen H; From the Department of Nuclear Medicine & Minnan PET Center.
Pang Y; From the Department of Nuclear Medicine & Minnan PET Center.
Meng T; From the Department of Nuclear Medicine & Minnan PET Center.
Yu X; Department of Thoracic Surgery, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Sun L; From the Department of Nuclear Medicine & Minnan PET Center.
Źródło:: Clinical nuclear medicine [Clin Nucl Med] 2021 May 01; Vol. 46 (5), pp. 424-426.
Typ publikacji:: Case Reports; Journal Article
Język:: English
Imprint Name(s):: Original Publication: Philadelphia, Lippincott.
MeSH Terms:: Fluorodeoxyglucose F18*
Positron Emission Tomography Computed Tomography*
Quinolines*
Lung Neoplasms/*diagnostic imaging
Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Female ; Humans ; Lung Neoplasms/pathology ; Middle Aged
References:: McDonald F, De Waele M, Hendriks LE, et al. Management of stage I and II nonsmall cell lung cancer. Eur Respir J . 2017;49:1600764.
Migliore M, Fornito M, Palazzolo M, et al. Ground glass opacities management in the lung cancer screening era. Ann Transl Med . 2018;6:90.
Higashi K, Ueda Y, Sakuma T, et al. Comparison of [(18)F]FDG PET and (201)Tl SPECT in evaluation of pulmonary nodules. J Nucl Med . 2001;42:1489–1496.
Heyneman LE, Patz EF. PET imaging in patients with bronchioloalveolar cell carcinoma. Lung Cancer . 2002;38:261–266.
Wu HB, Wang L, Wang QS, et al. Adenocarcinoma with BAC features presented as the nonsolid nodule is prone to be false-negative on 18 F-FDG PET/CT. Biomed Res Int . 2015;2015:243681.
Qin C, Gai Y, Liu Q, et al. Elevated 68 Ga-FAPI accumulation in a recurrent angiomyolipoma. Clin Nucl Med . 2020;45:1034–1035.
Zhu W, Guo F, Wang Y, et al. 68 Ga-FAPI-04 accumulation in myocardial infarction in a patient with neuroendocrine carcinoma. Clin Nucl Med . 2020;45:1020–1022.
Hao B, Wu X, Pang Y, et al. [(18)F]FDG and ([68)Ga]Ga-DOTA-FAPI-04 PET/CT in the evaluation of tuberculous lesions. Eur J Nucl Med Mol Imaging . 2021;48:651–652.
Chen H, Zhao L, Ruan D, et al. Usefulness of [(68)Ga]Ga-DOTA-FAPI-04 PET/CT in patients presenting with inconclusive [(18)F]FDG PET/CT findings. Eur J Nucl Med Mol Imaging . 2021;48:73–86.
Schmidkonz C, Rauber S, Atzinger A, et al. Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging. Ann Rheum Dis . 2020;79:1485–1491.
Substance Nomenclature:: 0 (68Ga-FAPI)
0 (Quinolines)
0Z5B2CJX4D (Fluorodeoxyglucose F18)
Entry Date(s):: Date Created: 20210330 Date Completed: 20210428 Latest Revision: 20230925
Update Code:: 20240105
DOI:: 10.1097/RLU.0000000000003600
PMID:: 33782300
: Czasopismo naukowe

Abstract: A 50-year-old woman with a newly detected pulmonary ground-glass opacity (GGO) nodule underwent PET/CT to determine the likelihood of malignancy. This patient was enrolled in the prospective study (NCT04588064) to determine the effectiveness of 18F-FDG and 68Ga-FAPI PET/CT for characterization of the GGO nodule. On PET/CT images, minimal 18F-FDG uptake but intense 68Ga-FAPI uptake was observed in this GGO nodule. This patient subsequently underwent video-assisted thoracoscopic surgery, and postoperative pathological examination confirmed the diagnosis of invasive adenocarcinoma. This case presented an example where 68Ga-FAPI PET/CT showed higher tracer uptake than 18F-FDG in the malignant GGO nodule.
Competing Interests: Conflicts of interest and sources of funding: none declared.
(Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

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