Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in central Iran.

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Abstrakt

Tytuł:: Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in central Iran.
Autorzy:: Abbasi E; Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran.
Ghaznavi-Rad E; Department of Microbiology and Immunology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran. .; Molecular and Medicine Research Center, Faculty of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran. .; Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Arak University of Medical Sciences, Arak, Iran. .
Źródło:: BMC gastroenterology [BMC Gastroenterol] 2021 Mar 30; Vol. 21 (1), pp. 140. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : BioMed Central, [2001-
MeSH Terms:: Quinolones*/pharmacology
Anti-Bacterial Agents/pharmacology ; Child ; Diarrhea/drug therapy ; Diarrhea/epidemiology ; Humans ; Integrons ; Iran/epidemiology ; Microbial Sensitivity Tests ; Salmonella/genetics
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Contributed Indexing:: Keywords: Antibiotic; Diarrhea; Iran; Quinolone resistance; Salmonella spp.
Substance Nomenclature:: 0 (Anti-Bacterial Agents)
0 (Quinolones)
Entry Date(s):: Date Created: 20210331 Date Completed: 20210514 Latest Revision: 20210514
Update Code:: 20240105
PubMed Central ID:: PMC8010990
DOI:: 10.1186/s12876-021-01719-3
PMID:: 33784974
: Czasopismo naukowe

Pełny tekst

Background: This study aimed to investigate the frequency and the antibiotic resistance patterns of Salmonella species that were isolated from infectious diarrhea samples taken from pediatric patients in central Iran.
Methods: The study analyzed 230 stool specimens that were cultured on XLD, MacConkey agar and GN broth. Polymerase chain reaction (PCR) assay was used to identify the Salmonella genus. The antibiotic resistance profiles and the frequency of quinolone and integron genes were obtained.
Results: Out of 230 samples of infectious diarrhea, 21 (9.1%) cases of Salmonella spp. were identified using culture methods. Another 28 (12.1%) samples had positive PCR results, with S. serovar Paratyphi B and C (9/21; 42.8%) and S. Typhi (3/21; 14.3%) being the most recognized. The highest antibiotic resistance rates were found for nalidixic acid (15/21; 71.4%), tetracycline (9/21; 42.8%). However, six (28.5%) of isolates were found resistant to cotrimoxazole, ampicillin and chloramphenicol. Among the plasmid-mediated quinolone resistance (PMQR) determinants, qnrS, qnrA, and qnrB were positive in (9/15; 60%), (6/15; 40%) and (3/15; 20%) of the isolates, respectively. Class 1 and 2 integrons were identified in 15 (71.4%) and 3 (14.3%) isolates, respectively.
Conclusion: High rates of quinolone resistant and low frequency of MDR Salmonella spp. isolates were identified in central Iran, similar to findings in other parts of Asia. To prevent the spread of these resistant strains, the antimicrobial resistance of Salmonella spp. isolates should be under constant surveillance, and empiric antibiotic therapy should be adapted appropriately.

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