Muscle oxygen extraction and lung function are related to exercise tolerance after allogeneic hematopoietic stem cell transplantation.

Tytuł:: Muscle oxygen extraction and lung function are related to exercise tolerance after allogeneic hematopoietic stem cell transplantation.
Autorzy:: Wakasugi T; Department of Rehabilitation, Hyogo College of Medicine College Hospital, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan. .
Morishita S; Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.; Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Kaida K; Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Ikegame K; Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Uchiyama Y; Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Domen K; Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Źródło:: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2021 Oct; Vol. 29 (10), pp. 6039-6048. Date of Electronic Publication: 2021 Mar 30.
Typ publikacji:: Journal Article; Observational Study
Język:: English
Imprint Name(s):: Original Publication: Berlin : Springer International, c1993-
MeSH Terms:: Exercise Tolerance*
Hematopoietic Stem Cell Transplantation*/adverse effects
Humans ; Lung ; Muscle, Skeletal ; Oxygen ; Prospective Studies
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Grant Information:: 18H00508 KAKENHI; 17H00696 KAKENHI; 16H00708 KAKENHI
Contributed Indexing:: Keywords: Cancer; Cardiopulmonary function; Exercise; Hemoglobin; Muscle; NIRS
Substance Nomenclature:: S88TT14065 (Oxygen)
Entry Date(s):: Date Created: 20210331 Date Completed: 20211015 Latest Revision: 20211015
Update Code:: 20240104
DOI:: 10.1007/s00520-021-06178-w
PMID:: 33786668
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Purpose: This study aimed to investigate the relationship between exercise intolerance, muscle oxidative metabolism, and cardiopulmonary function following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a sterile isolation room setting.
Methods: This was a prospective observational cohort study conducted in a single center. Fourteen patients with hematopoietic malignancies who had undergone allo-HSCT were included in this study from June 2015 to April 2020. Patients received donor HSCT after high dose-chemotherapy and total-body irradiation. Physical activity was limited during treatments. Outcome measures included body anthropometric measurements, exercise tolerance tests using the ramp protocol, pulmonary function tests, and near-infrared spectroscopy (NIRS) measurements. Data of pre- and posttransplant measurements were compared using the paired t test or nonparametric Wilcoxon U test. Associations were assessed using the Pearson or nonparametric Spearman correlations.
Results: NIRS showed reduced muscle consumption and extraction of oxygen in the posttransplant period compared to the pretransplant period (ΔStO 2 min pre: -18.6% vs. post: -13.0%, P = 0.04; ΔHHb max pre: 4.21μmol/l vs. post: 3.31μmol/l: P = 0.048). Exercise tolerance had reduced following allo-HSCT (Peak workload pre: 70.3 W vs. post: 58.0 W: P = 0.014). Furthermore, exercise intolerance was associated with pulmonary function, muscle oxygen consumption, and muscle oxygen extraction (all P <0.05).
Conclusion: This analysis revealed that exercise intolerance following allo-HSCT was associated with pulmonary dysfunction and muscle oxidative dysfunction. These findings could help identify the physical function associated with impaired tissue oxygen transport leading to exercise intolerance following allo-HSCT.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Erratum in: Support Care Cancer. 2021 Apr 20;:. (PMID: 33877409)

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