Phenotypic heterogeneity, stability and plasticity in tumor-promoting carcinoma-associated fibroblasts.

Tytuł:: Phenotypic heterogeneity, stability and plasticity in tumor-promoting carcinoma-associated fibroblasts.
Autorzy:: Mezawa Y; Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan.
Orimo A; Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan.
Źródło:: The FEBS journal [FEBS J] 2022 May; Vol. 289 (9), pp. 2429-2447. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Oxford, UK : Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies, c2005-
MeSH Terms:: Cancer-Associated Fibroblasts*/metabolism
Carcinoma*/metabolism
Fibroblasts/metabolism ; Humans ; Phenotype ; Tumor Microenvironment/genetics
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Contributed Indexing:: Keywords: activated fibroblastic phenotypes; carcinoma-associated fibroblasts; plasticity; stability; tumor microenvironment
Entry Date(s):: Date Created: 20210331 Date Completed: 20220504 Latest Revision: 20220611
Update Code:: 20240104
DOI:: 10.1111/febs.15851
PMID:: 33786982
: Czasopismo naukowe

Pełny tekst

Reciprocal interactions between cancer cells and stromal cells in the tumor microenvironment (TME) are essential for full-blown tumor development. Carcinoma-associated fibroblasts (CAFs) are a key component of the TME together with a wide variety of stromal cell types including vascular, inflammatory, and immune cells in the extracellular matrix. CAFs not only promote tumor growth, invasion, and metastasis, but also dampen the efficacy of various therapies including immune checkpoint inhibitors. CAFs are composed of distinct fibroblast populations presumably with diverse activated fibroblastic states and tumor-promoting phenotypes in a tumor, indicating intratumor heterogeneity in these fibroblasts. Given that CAFs have been implicated in both disease progression and therapeutic responses, elucidating the functional roles of each fibroblast population in CAFs and the molecular mechanisms mediating their phenotypic stability and plasticity in the TME would be crucial for understanding tumor biology. We herein discuss how distinct fibroblast populations comprising CAFs establish their cell identities, in terms of cells-of-origin, stimuli from the TME, and the phenotypes characteristic of activated states.
(© 2021 Federation of European Biochemical Societies.)

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