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Tytuł:
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Effect of Mild Traumatic Brain Injury on Behavioral Reactions and Neocortical Morphology in Rats.
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Autorzy:
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Plekhova NG; Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia. pl_.
Radkov IV; Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia.
Zinoviev SV; Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia.
Dyuizen IV; A. V. Zhirmunsky Institute of Marine Biology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
Baryshev AN; A. V. Zhirmunsky Institute of Marine Biology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok, Russia.
Shumatov VB; Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia.
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Źródło:
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Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2021 Mar; Vol. 170 (5), pp. 672-676. Date of Electronic Publication: 2021 Mar 31.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
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MeSH Terms:
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Brain Injuries/*physiopathology
Brain Injuries, Traumatic/*physiopathology
Animals ; Brain/metabolism ; Brain/physiology ; Brain Concussion/physiopathology ; Disease Models, Animal ; Male ; Neocortex/physiology ; Neurons/metabolism ; Neurons/physiology ; Rats ; Rats, Wistar
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References:
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Radkov IV, Laptev VV, Plekhova NG. Technologies of modeling the diffuse traumatic brain injury. Sovremen. Probl. Nauki Obrazovaniya. 2018;(4):148. Russian.
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Contributed Indexing:
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Keywords: behavioral phenotype; experimental model; neocortex; rats; traumatic brain injury
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Entry Date(s):
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Date Created: 20210331 Date Completed: 20220110 Latest Revision: 20220110
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Update Code:
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20240104
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DOI:
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10.1007/s10517-021-05130-6
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PMID:
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33788107
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The original weight-drop model was employed to examine the effect of mild traumatic brain injury (TBI) on behavioral phenotype and neocortical morphology in rats. The neurological examination of rats with moderate TBI revealed the focal symptoms corresponding to pronounced neurological disorders, whereas in rats after mild TBI, there were only minor coordination disorders. On day 7 after injury, the rats with mild TBI demonstrated enhanced anxiety assessed by conditioned passive avoidance response. The morphometric analysis of the brain tissues revealed narrowing of the capillaries and increased score of hyperchromic neocortical neurons, which attested to cerebral hypoxia. The manifestations of mild TBI in original rat model demonstrated a close similarity to the symptoms of TBI in humans.