Weight-bearing exercise prevents skeletal muscle atrophy in ovariectomized rats.

Szczegóły
Abstrakt

Tytuł:: Weight-bearing exercise prevents skeletal muscle atrophy in ovariectomized rats.
Autorzy:: Tang L; Institute of Sports Biology, Shaanxi Normal University, Xi'an, 710119, China.
Cao W; Institute of Sports Biology, Shaanxi Normal University, Xi'an, 710119, China.
Zhao T; Institute of Sports Biology, Shaanxi Normal University, Xi'an, 710119, China.
Yu K; Institute of Sports Biology, Shaanxi Normal University, Xi'an, 710119, China.
Sun L; Institute of Sports Biology, Shaanxi Normal University, Xi'an, 710119, China.
Guo J; Shaanxi Key Laboratory of Ultrasonics, Shaanxi Normal University, Xi'an, China.
Fan X; Institute of Sports Biology, Shaanxi Normal University, Xi'an, 710119, China. .
Ta D; Department of Electronic Engineering, Fudan University, Shanghai, 200433, China. .; Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention (MICCAI) of Shanghai, Shanghai, China. .
Źródło:: Journal of physiology and biochemistry [J Physiol Biochem] 2021 May; Vol. 77 (2), pp. 273-281. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Pamplona, Spain : Servicio de Publicaciones de la Universidad De Navarra (departamentos de fisiología y nutrición y de bioquimica), [1998-
MeSH Terms:: Weight-Bearing*
Muscle, Skeletal/*metabolism
Muscular Atrophy/*genetics
Muscular Atrophy/*prevention & control
Physical Conditioning, Animal/*methods
Signal Transduction/*genetics
Activin Receptors, Type II/genetics ; Activin Receptors, Type II/metabolism ; Animals ; Estrogens/deficiency ; Female ; Gene Expression Regulation ; Muscle, Skeletal/physiopathology ; Muscular Atrophy/etiology ; Muscular Atrophy/physiopathology ; Myostatin/genetics ; Myostatin/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Ovariectomy/adverse effects ; Ovary/metabolism ; Ovary/surgery ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
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Grant Information:: 11774213 National Natural Science Foundation of China; 2018JM1022 Natural Science Foundation of Shaanxi Province; GK201703092 Fundamental Research Funds for the Central Universities; GK201703091 Fundamental Research Funds for the Central Universities; QN2018004 Projection of Young Teachers Research Achievements Training
Contributed Indexing:: Keywords: Skeletal muscle atrophy,·Estrogen deficiency,·Ovariectomized rats,·Myostatin,·Signaling pathway; Weight-bearing exercise
Substance Nomenclature:: 0 (Estrogens)
0 (Mstn protein, rat)
0 (Myostatin)
0 (Nerve Tissue Proteins)
0 (Foxo1 protein, rat)
EC 2.7.1.1 (mTOR protein, rat)
EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
EC 2.7.11.1 (TOR Serine-Threonine Kinases)
EC 2.7.11.30 (Activin Receptors, Type II)
EC 2.7.11.30 (activin receptor type II-B)
Entry Date(s):: Date Created: 20210331 Date Completed: 20210806 Latest Revision: 20221207
Update Code:: 20240104
DOI:: 10.1007/s13105-021-00794-0
PMID:: 33788149
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Skeletal muscle atrophy (SMA) is a dominant symptom induced by estrogen deficiency which can lead to severe health problems of postmenopausal women. Furthermore, estrogen deficiency has severely compromised the maintenance of muscle stem cells as well as impairs self-renewal and differentiation into muscle fibers. Resistance training is commonly considered as a positive and useful intervention in accelerating the rate of muscle growth. As one of the resistance training, whether the weight-bearing exercise can alleviate SMA induced by estrogen deficiency has not been investigated. The rats were divided into 3 groups randomly: sham group, ovariectomized (OVX) group, and weight-bearing exercise (WBE) therapeutic group. The weight that rats were loaded was 35% of their body weight, and the rats were trained by treadmill training (5° slope, 20 m/min, 30 min/day, 6 days/week) for 8 weeks. After training, the quality and strength of skeletal muscle of the WBE rats were improved; meanwhile, the cross-sectional areas of the skeletal muscle were also increased. Moreover, the WBE activated Akt significantly, upregulated the expression of mTOR, and downregulated the expression of MSTN and its receptor ActRIIB and FoxO1, respectively. The SMA phenomena of rats which induced by estrogen deficiency were prevented effectively via WBE, and the MSTN/Akt/mTOR and FoxO1 signaling pathway may be the predominant way in this improvement.

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