Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD-MOD).

Szczegóły
Abstrakt

Tytuł:: Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD-MOD).
Autorzy:: Galvin JE; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Chrisphonte S; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Cohen I; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Greenfield KK; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Kleiman MJ; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Moore C; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Riccio ML; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Rosenfeld A; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Shkolnik N; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Walker M; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Chang LC; Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, Florida, USA.
Tolea MI; Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Źródło:: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2021 Oct; Vol. 17 (10), pp. 1675-1686. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd.
Original Publication: Orlando, FL : Elsevier, Inc.
MeSH Terms:: Diagnosis, Differential*
Cognitive Dysfunction/*diagnosis
Lewy Body Disease/*diagnosis
Aged ; Alzheimer Disease/diagnosis ; Cross-Sectional Studies ; Female ; Humans ; Male ; Neuropsychological Tests ; Parkinsonian Disorders/etiology ; REM Sleep Behavior Disorder/etiology
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Grant Information:: R01 AG040211 United States AG NIA NIH HHS; R01 AG071514 United States AG NIA NIH HHS; R01 NS101483 United States NS NINDS NIH HHS
Contributed Indexing:: Keywords: Alzheimer's Disease Center program; Alzheimer's disease; DLB; Lewy body composite risk score; dementia; dementia with Lewy bodies; mild cognitive impairment; module; uniform data set
Entry Date(s):: Date Created: 20210401 Date Completed: 20211229 Latest Revision: 20240403
Update Code:: 20240403
PubMed Central ID:: PMC8484363
DOI:: 10.1002/alz.12334
PMID:: 33793069
: Czasopismo naukowe

Introduction: The National Institute on Aging Alzheimer's Disease Research Center program added the Lewy body dementia module (LBD-MOD) to the Uniform Data Set to facilitate LBD characterization and distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). We tested the performance of the LBD-MOD.
Methods: The LBD-MOD was completed in a single-site study in 342 participants: 53 controls, 78 AD, and 110 DLB; 79 mild cognitive impairment due to AD (MCI-AD); and 22 MCI-DLB.
Results: DLB differed from AD in extrapyramidal symptoms, hallucinations, apathy, autonomic features, REM sleep behaviors, daytime sleepiness, cognitive fluctuations, timed attention tasks, and visual perception. MCI-DLB differed from MCI-AD in extrapyramidal features, mood, autonomic features, fluctuations, timed attention tasks, and visual perception. Descriptive data on LBD-MOD measures are provided for reference.
Discussion: The LBD-MOD provided excellent characterization of core and supportive features to differentiate DLB from AD and healthy controls while also characterizing features of MCI-DLB.
(© 2021 the Alzheimer's Association.)

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