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Tytuł:
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Seroprevalence of hospital staff in a province with zero COVID-19 cases.
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Autorzy:
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Nopsopon T; Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Pongpirul K; Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.; Bumrungrad International Hospital, Bangkok, Thailand.
Chotirosniramit K; Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Jakaew W; Ranong Hospital, Ranong, Thailand.
Kaewwijit C; Ranong Hospital, Ranong, Thailand.
Kanchana S; Ranong Hospital, Ranong, Thailand.
Hiransuthikul N; Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
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Źródło:
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PloS one [PLoS One] 2021 Apr 01; Vol. 16 (4), pp. e0238088. Date of Electronic Publication: 2021 Apr 01 (Print Publication: 2021).
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: San Francisco, CA : Public Library of Science
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MeSH Terms:
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Antibodies, Viral/*blood
COVID-19/*epidemiology
Immunoglobulin G/*blood
Immunoglobulin M/*blood
Personnel, Hospital/*statistics & numerical data
Adult ; Female ; Humans ; Male ; Middle Aged ; Seroepidemiologic Studies ; Thailand/epidemiology
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References:
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Substance Nomenclature:
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0 (Antibodies, Viral)
0 (Immunoglobulin G)
0 (Immunoglobulin M)
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Entry Date(s):
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Date Created: 20210401 Date Completed: 20210413 Latest Revision: 20210413
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Update Code:
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20240104
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PubMed Central ID:
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PMC8016267
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DOI:
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10.1371/journal.pone.0238088
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PMID:
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33793556
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Background: COVID-19 seroprevalence data, particularly in less developed countries with a relatively low incidence, has been scant. We aimed to explore the seroprevalence of hospital staff in the area with zero confirmed COVID-19 case to shed light on the situation of COVID-19 infection in zero or low infection rate countries where mass screening was not readily available.
Methods: A locally developed rapid immunoglobulin M (IgM)/immunoglobulin G (IgG) test kit was used for hospital staff screening of Ranong hospital which is located in a province with zero COVID-19 prevalence in Thailand from 17th April to 17th May 2020. All staff was tested, 100 of which were randomly invited to have a repeating antibody test in one month. (Thai Clinical Trials Registry: TCTR20200426002).
Results: Of 844 hospital staff, 82 were tested twice one month apart (response rate for repeating antibody test 82%). Overall, 0.8% of the participants (7 of 844) had positive IgM, none had positive IgG. Female staff had 1.0% positive IgM (95% CI: 0.5-2.1%) while male had 0.5% positive IgM (95% CI: 0.1-2.6%). No participants with a history of travel to the high-risk area or close contact with PCR-confirmed COVID-19 case developed SARS-CoV-2 antibodies. Among 844 staff, 811 had no symptoms and six of them developed IgM seropositive (0.7%) while 33 had minor symptoms and only one of them developed IgM seropositive (3.0%). No association between SARS-CoV-2 IgM status and gender, history of travel to a high-risk area, close contact with PCR-confirmed or suspected COVID-19 case, presence of symptoms within 14 days, or previous PCR status was found. None of the hospital staff developed SARS-CoV-2 IgG.
Conclusions: COVID-19 antibody test could detect a considerable number of hospital staff who could be potential silent spreaders in a province with zero COVID-19 cases. Accurate antibody testing is a valuable screening tool, particularly in asymptomatic healthcare workers. Trial registration: This study was approved by the Institutional Review Board of Chulalongkorn University (IRB No.236/63) and the Institutional Review Board of Ranong Hospital. (Thai Clinical Trials Registry: TCTR20200426002).
Competing Interests: The authors have declared that no competing interests exist.
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