Folate Levels in Patients Hospitalized with Coronavirus Disease 2019.

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Tytuł:: Folate Levels in Patients Hospitalized with Coronavirus Disease 2019.
Autorzy:: Meisel E; Department of Internal Medicine 'D', Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Efros O; Department of Internal Medicine 'D', Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; National Hemophilia Center and Institute of Thrombosis & Hemostasis, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.
Bleier J; Department of Internal Medicine 'D', Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Beit Halevi T; Department of Internal Medicine 'D', Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Segal G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Department of Internal Medicine 'T', Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.
Rahav G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Infectious Disease Unit, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.
Leibowitz A; Department of Internal Medicine 'D', Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Grossman E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Internal Medicine Wing, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.
Źródło:: Nutrients [Nutrients] 2021 Mar 02; Vol. 13 (3). Date of Electronic Publication: 2021 Mar 02.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI Publishing
MeSH Terms:: COVID-19/*blood
Folic Acid/*blood
Aged ; COVID-19/diagnosis ; COVID-19/epidemiology ; Female ; Folic Acid Deficiency/blood ; Folic Acid Deficiency/complications ; Hospitalization/statistics & numerical data ; Humans ; Israel/epidemiology ; Length of Stay ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors
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Contributed Indexing:: Keywords: COVID-19; SARS CoV-2; epidemic; folate; folate deficiency; folic acid; folic acid deficiency; hypoxemia; invasive ventilation
Substance Nomenclature:: 935E97BOY8 (Folic Acid)
Entry Date(s):: Date Created: 20210403 Date Completed: 20210412 Latest Revision: 20210413
Update Code:: 20240104
PubMed Central ID:: PMC8001221
DOI:: 10.3390/nu13030812
PMID:: 33801194
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We aimed to investigate the prevalence of decreased folate levels in patients hospitalized with Coronavirus Disease 2019 (COVID-19) and evaluate their outcome and the prognostic signifi-cance associated with its different levels. In this retrospective cohort study, data were obtained from the electronic medical records at the Sheba Medical Center. Folic acid levels were available in 333 out of 1020 consecutive patients diagnosed with COVID-19 infection hospitalized from January 2020 to November 2020. Thirty-eight (11.4%) of the 333 patients comprising the present study population had low folate levels. No significant difference was found in the incidence of acute kidney injury, hypoxemia, invasive ventilation, length of hospital stay, and mortality be-tween patients with decreased and normal-range folate levels. When sub-dividing the study population according to quartiles of folate levels, similar findings were observed. In conclusion, decreased serum folate levels are common among hospitalized patients with COVID-19, but there was no association between serum folate levels and clinical outcomes. Due to the important role of folate in cell metabolism and the potential pathologic impact when deficient, a follow-up of folate levels or possible supplementation should be encouraged in hospitalized COVID-19 patients. Fur-ther studies are required to assess the prevalence and consequences of folate deficiency in COVID-19 patients.

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