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Tytuł pozycji:

Intense Pulsed Light Attenuates UV-Induced Hyperimmune Response and Pigmentation in Human Skin Cells.

Tytuł:
Intense Pulsed Light Attenuates UV-Induced Hyperimmune Response and Pigmentation in Human Skin Cells.
Autorzy:
Kim J; R&D Unit, Amorepacific Corporation, Yongin 17074, Korea.
Lee J; R&D Unit, Amorepacific Corporation, Yongin 17074, Korea.
Choi H; R&D Unit, Amorepacific Corporation, Yongin 17074, Korea.
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 20; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 20.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:
Intense Pulsed Light Therapy*
Hypersensitivity/*etiology
Hypersensitivity/*therapy
Pigmentation Disorders/*etiology
Pigmentation Disorders/*therapy
Ultraviolet Rays/*adverse effects
Antioxidants/metabolism ; Biomarkers ; Cells, Cultured ; Cytokines/metabolism ; Dermatitis/etiology ; Dermatitis/metabolism ; Dermatitis/pathology ; Humans ; Hypersensitivity/pathology ; Melanins/biosynthesis ; Oxidative Stress/radiation effects ; Phototherapy ; Pigmentation/radiation effects ; Pigmentation Disorders/metabolism ; Pigmentation Disorders/pathology ; Reactive Oxygen Species/metabolism ; Skin/metabolism ; Skin/pathology ; Skin/radiation effects ; Skin Aging/radiation effects
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Contributed Indexing:
Keywords: antioxidative enzyme activity; inflammation; intense pulsed light; melanogenesis; oxidative stress; photoaging
Substance Nomenclature:
0 (Antioxidants)
0 (Biomarkers)
0 (Cytokines)
0 (Melanins)
0 (Reactive Oxygen Species)
Entry Date(s):
Date Created: 20210403 Date Completed: 20210512 Latest Revision: 20210512
Update Code:
20240104
PubMed Central ID:
PMC8003787
DOI:
10.3390/ijms22063173
PMID:
33804685
Czasopismo naukowe
The skin of an organism is affected by various environmental factors and fights against aging stress via mechanical and biochemical responses. Photoaging induced by ultraviolet B (UVB) irradiation is common and is the most vital factor in the senescence phenotype of skin, and so, suppression of UVB stress-induced damage is critical. To lessen the UVB-induced hyperimmune response and hyperpigmentation, we investigated the ameliorative effects of intense pulsed light (IPL) treatment on the photoaged phenotype of skin cells. Normal human epidermal keratinocytes and human epidermal melanocytes were exposed to 20 mJ/cm 2 of UVB. After UVB irradiation, the cells were treated with green (525-530 nm) and yellow (585-592 nm) IPL at various time points prior to the harvest step. Subsequently, various signs of excessive immune response, including expression of proinflammatory and melanogenic genes and proteins, cellular oxidative stress level, and antioxidative enzyme activity, were examined. We found that IPL treatment reduced excessive cutaneous immune reactions by suppressing UVB-induced proinflammatory cytokine expression. IPL treatment prevented hyperpigmentation, and combined treatment with green and yellow IPL synergistically attenuated both processes. IPL treatment may exert protective effects against UVB injury in skin cells by attenuating inflammatory cytokine and melanogenic gene overexpression, possibly by reducing intracellular oxidative stress. IPL treatment also preserves antioxidative enzyme activity under UVB irradiation. This study suggests that IPL treatment is a useful strategy against photoaging, and provides evidence supporting clinical approaches with non-invasive light therapy.

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