Reduced post-exercise muscle microvascular perfusion with compression is offset by increased muscle oxygen extraction: Assessment by contrast-enhanced ultrasound.

Szczegóły
Abstrakt

Tytuł:: Reduced post-exercise muscle microvascular perfusion with compression is offset by increased muscle oxygen extraction: Assessment by contrast-enhanced ultrasound.
Autorzy:: Broatch JR; Institute for Health and Sport (IHES), Victoria University, Melbourne, VIC, Australia.; Australia Institute of Sport, Canberra, ACT, Australia.
O'Riordan SF; Institute for Health and Sport (IHES), Victoria University, Melbourne, VIC, Australia.; Australia Institute of Sport, Canberra, ACT, Australia.
Keske MA; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.
Betik AC; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.
Bishop DJ; Institute for Health and Sport (IHES), Victoria University, Melbourne, VIC, Australia.
Halson SL; School of Behavioural and Health Sciences, Australian Catholic University, Melbourne, VIC, Australia.
Parker L; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.
Źródło:: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 May; Vol. 35 (5), pp. e21499.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2020- : [Bethesda, Md.] : Hoboken, NJ : Federation of American Societies for Experimental Biology ; Wiley
Original Publication: [Bethesda, Md.] : The Federation, [c1987-
MeSH Terms:: Exercise*
Hemodynamics*
Microcirculation*
Oxygen Consumption*
Regional Blood Flow*
Muscle, Skeletal/*physiology
Oxygen/*metabolism
Adult ; Case-Control Studies ; Exercise Tolerance ; Female ; Humans ; Male ; Muscle, Skeletal/diagnostic imaging ; Perfusion ; Ultrasonography
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Contributed Indexing:: Keywords: NIRS; capillary-myocyte interface; ergogenic; microvasculature; sprint-interval exercise
Substance Nomenclature:: S88TT14065 (Oxygen)
Entry Date(s):: Date Created: 20210403 Date Completed: 20210720 Latest Revision: 20210720
Update Code:: 20240105
DOI:: 10.1096/fj.202002205RR
PMID:: 33811697
: Czasopismo naukowe

The microvasculature is important for both health and exercise tolerance in a range of populations. However, methodological limitations have meant changes in microvascular blood flow are rarely assessed in humans during interventions designed to affect skeletal muscle blood flow such as the wearing of compression garments. The aim of this study is, for the first time, to use contrast-enhanced ultrasound to directly measure the effects of compression on muscle microvascular blood flow alongside measures of femoral artery blood flow and muscle oxygenation following intense exercise in healthy adults. It was hypothesized that both muscle microvascular and femoral artery blood flows would be augmented with compression garments as compared with a control condition. Ten recreationally active participants completed two repeated-sprint exercise sessions, with and without lower-limb compression tights. Muscle microvascular blood flow, femoral arterial blood flow (2D and Doppler ultrasound), muscle oxygenation (near-infrared spectroscopy), cycling performance, and venous blood samples were measured/taken throughout exercise and the 1-hour post-exercise recovery period. Compared with control, compression reduced muscle microvascular blood volume and attenuated the exercise-induced increase in microvascular velocity and flow immediately after exercise and 1 hour post-exercise. Compression increased femoral artery diameter and augmented the exercise-induced increase in femoral arterial blood flow during exercise. Markers of blood oxygen extraction in muscle were increased with compression during and after exercise. Compression had no effect on blood lactate, glucose, or exercise performance. We provide new evidence that lower-limb compression attenuates the exercise-induced increase in skeletal muscle microvascular blood flow following exercise, despite a divergent increase in femoral artery blood flow. Decreased muscle microvascular perfusion is offset by increased muscle oxygen extraction, a potential mechanism allowing for the maintenance of exercise performance.
(© 2021 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.)

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